(S)-tert-butyl 2-((2,4-difluorophenoxy)methyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: (S)-tert-butyl 2-((2,4-difluorophenoxy)methyl)pyrrolidine-1-carboxylate
• CAS No.: 1092522-49-0
• Molecular Formula: C₁₆H₂₁F₂NO₃
• Molecular Weight: 313.344

Synonyms:(S)-tert-butyl 2-((2,4-difluorophenoxy)methyl)pyrrolidine-1-carboxylate

Chemical Property of (S)-tert-butyl 2-((2,4-difluorophenoxy)methyl)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 2-((2,4-difluorophenoxy)methyl)pyrrolidine-1-carboxylate

There total 2 articles about (S)-tert-butyl 2-((2,4-difluorophenoxy)methyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2,4-difluorophenol (367-27-1) + (S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate (86661-32-7) → (S)-tert-butyl 2-((2,4-difluorophenoxy)methyl)pyrrolidine-1-carboxylate (1092522-49-0)

Guidance literature:

2,4-difluorophenol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.5h; Inert atmosphere;

(S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate; In N,N-dimethyl-formamide; mineral oil; at 80 ℃; for 17h; Inert atmosphere;

DOI:10.1021/jm801107u

Reference yield: 58.0%

→ (S)-tert-butyl 2-((2,4-difluorophenoxy)methyl)pyrrolidine-1-carboxylate (1092522-49-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.5h;

In N,N-dimethyl-formamide; at 80 ℃; for 17h;

Reference yield:

(S)-tert-butyl 2-((2,4-difluorophenoxy)methyl)pyrrolidine-1-carboxylate (1092522-49-0) → C11H13F2NO (1226205-37-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm801107u

upstream raw materials:

2,4-difluorophenol

(S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate

Downstream raw materials:

C₁₁H₁₃F₂NO

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1092522-49-0 (S)-tert-butyl 2-((2,4-difluorophenoxy)methyl)pyrrolidine-1-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send