5-(2,6-difluorophenyl)-3-{[1-(trifluoromethanesulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide

Base Information

Chemical Name:5-(2,6-difluorophenyl)-3-{[1-(trifluoromethanesulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide
CAS No.:1253733-93-5
Molecular Formula:C₂₃H₁₉F₅N₆O₃S
Molecular Weight:554.5
Hs Code.:

Synonyms:5-(2,6-difluorophenyl)-3-{[1-(trifluoromethanesulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide

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Chemical Property of 5-(2,6-difluorophenyl)-3-{[1-(trifluoromethanesulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide

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Technology Process of 5-(2,6-difluorophenyl)-3-{[1-(trifluoromethanesulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide

There total 12 articles about 5-(2,6-difluorophenyl)-3-{[1-(trifluoromethanesulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253733-97-9
5-(2,6-difluorophenyl)-3-{[1-(trifluoromethanesulphonyl)piperidin-4-yl]amino}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide

: 1253733-93-5
5-(2,6-difluorophenyl)-3-{[1-(trifluoromethanesulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1253733-93-5
5-(2,6-difluorophenyl)-3-{[1-(trifluoromethanesulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dmap / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

2.1: dichloromethane / 1 h / 20 °C

3.1: 1,4-dioxane / 0.17 h / Inert atmosphere

3.2: 2 h / Reflux

4.1: sodium hydroxide / ethanol; tetrahydrofuran / Inert atmosphere; Reflux

4.2: 3 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With triethylamine; trifluoroacetic acid; sodium hydroxide; dmap; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 1253733-68-4
3-(4-iodophenyl)-1H-pyrazol-4-ylamine

: 1253733-93-5
5-(2,6-difluorophenyl)-3-{[1-(trifluoromethanesulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: pyridine / dichloromethane / 3 h / 0 - 20 °C

2.1: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere

3.1: 0.17 h / Inert atmosphere

3.2: 1.5 h / 130 °C

4.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C

5.1: potassium hydroxide; bromine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

7.1: 1,4-dioxane / 0.17 h / Inert atmosphere

7.2: 2 h / Reflux

8.1: sodium hydroxide / ethanol; tetrahydrofuran / Inert atmosphere; Reflux

8.2: 3 h / 20 °C

9.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With pyridine; phosphorus pentoxide; bromine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;