2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-phenylcyclopropanecarboxylate

Base Information

Chemical Name:2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-phenylcyclopropanecarboxylate
CAS No.:108546-90-3
Molecular Formula:C₃₂H₃₈O₃
Molecular Weight:470.652
Hs Code.:

Synonyms:2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-phenylcyclopropanecarboxylate

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Chemical Property of 2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-phenylcyclopropanecarboxylate

Chemical Property:

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Technology Process of 2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-phenylcyclopropanecarboxylate

There total 4 articles about 2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-phenylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 100-52-7
benzaldehyde

: 108546-83-4
2,6-di(tert-butyl)-4-methylphenyl 2-phenylcyclopropanecarboxylate

: 108546-90-3
2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-phenylcyclopropanecarboxylate

Guidance literature:: With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 0.0833333h; 1.) 30 min;
DOI:10.1002/hlca.19860690720

Reference yield:

: 5685-38-1
2-phenyl-cyclopropanecarboxylic acid

: 108546-90-3
2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-phenylcyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂

2: 42 percent / 1.) BuLi in hexane / tetrahydrofuran / 24 h / Ambient temperature; 1.) 10 min

3: 53 percent / 1.) t-BuLi in pentane / tetrahydrofuran / 0.08 h / -78 °C / 1.) 30 min

With n-butyllithium; thionyl chloride; tert.-butyl lithium; In tetrahydrofuran;
DOI:10.1002/hlca.19860690720

Reference yield:

: 946-38-3,946-39-4,34702-96-0,34702-97-1,34703-00-9,34716-60-4,63038-62-0,63038-63-1,97-71-2
ethyl 2-phenylcyclopropylcarboxylate

: 108546-90-3
2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-phenylcyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: KOH / H₂O; ethanol

2: SOCl₂

3: 42 percent / 1.) BuLi in hexane / tetrahydrofuran / 24 h / Ambient temperature; 1.) 10 min

4: 53 percent / 1.) t-BuLi in pentane / tetrahydrofuran / 0.08 h / -78 °C / 1.) 30 min

With potassium hydroxide; n-butyllithium; thionyl chloride; tert.-butyl lithium; In tetrahydrofuran; ethanol; water;
DOI:10.1002/hlca.19860690720