108546-83-4

Upstream product

• 100-42-5 styrene 
• 125640-92-8 2,6-di-tert-butyl-4-methylphenyl diazoacetate 
• 5685-38-1 2-phenyl-cyclopropanecarboxylic acid 
• 946-38-3 ethyl 2-phenylcyclopropylcarboxylate 
• 128-37-0 2,6-di-tert-butyl-4-methyl-phenol 
• 939-87-7 2-phenyl-1-cyclopropanecarbonyl chloride 
• 125641-00-1 2,6-Bis(1,1-dimethylethyl)-4-methylphenyl 2-diazo-3-butenoate 

Downstream Products

• 1570-90-7 1-benzyl-2-phenylcyclopropanecarboxylic acid 
• 108546-90-3 2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-phenylcyclopropanecarboxylate 

Relevant academic research and scientific papers

Exceptionally high trans (anti) stereoselectivity in catalytic cyclopropanation reactions

Exceptionally high trans (anti) stereoselectivities are obtained in rhodium(II) carboxylate and carboxamide catalyzed alkene cyclopropanation reactions with 2,6-di-tert-butyl-4-methylphenyl diazoacetate (BDA). With monosubstituted ethylenes, use of rhodiu

Generation and Reactions of Lithiated tert-Butyl and 2,6-Di(tert-butyl)-4-methylphenyl Cyclopropanecarboxylates

tert-Butyl and 2,6-di(tert-butyl)-4-methylphenyl (BHT) cyclopropanecarboxylates (4, 6, 24, 25) are lithiated with LiN(i-Pr)2 and t-BuLi, respectively.Reactions with alkyl halides, aldehydes, acyl chlorides, and heteroelectrophiles give α-substituted BHT esters which can be cleaved (t-BuOK/H2O/THF) to the corresponding carboxylic acids or reduced (LiAlH4/THF) to the cyclopropanemethanols.