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1640128-68-2

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1640128-68-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1640128-68-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,4,0,1,2 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1640128-68:
(9*1)+(8*6)+(7*4)+(6*0)+(5*1)+(4*2)+(3*8)+(2*6)+(1*8)=142
142 % 10 = 2
So 1640128-68-2 is a valid CAS Registry Number.

1640128-68-2Relevant articles and documents

COMBINATION THERAPY INCLUDING AN MDM2 INHIBITOR AND ONE OR MORE ADDITIONAL PHARMACEUTICALLY ACTIVE AGENTS FOR THE TREATMENT OF CANCERS

-

, (2015/05/26)

The present invention provides combination therapy that includes an MDM2 inhibitor and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain

Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction

Rew, Yosup,Sun, Daqing,Yan, Xuelei,Beck, Hilary P.,Canon, Jude,Chen, Ada,Duquette, Jason,Eksterowicz, John,Fox, Brian M.,Fu, Jiasheng,Gonzalez, Ana Z.,Houze, Jonathan,Huang, Xin,Jiang, Min,Jin, Lixia,Li, Yihong,Li, Zhihong,Ling, Yun,Lo, Mei-Chu,Long, Alexander M.,McGee, Lawrence R.,McIntosh, Joel,Oliner, Jonathan D.,Osgood, Tao,Saiki, Anne Y.,Shaffer, Paul,Wang, Yu Chung,Wortman, Sarah,Yakowec, Peter,Ye, Qiuping,Yu, Dongyin,Zhao, Xiaoning,Zhou, Jing,Medina, Julio C.,Olson, Steven H.

, p. 10499 - 10511 (2015/02/19)

Structure-based rational design and extensive structure-activity relationship studies led to the discovery of AMG 232 (1), a potent piperidinone inhibitor of the MDM2-p53 association, which is currently being evaluated in human clinical trials for the treatment of cancer. Further modifications of 1, including replacing the carboxylic acid with a 4-amidobenzoic acid, afforded AM-7209 (25), featuring improved potency (KD from ITC competition was 38 pM, SJSA-1 EdU IC50 = 1.6 nM), remarkable pharmacokinetic properties, and in vivo antitumor activity in both the SJSA-1 osteosarcoma xenograft model (ED50 = 2.6 mg/kg QD) and the HCT-116 colorectal carcinoma xenograft model (ED50 = 10 mg/kg QD). In addition, 25 possesses distinct mechanisms of elimination compared to 1.

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