Technology Process of ethyl 2-[(2R,4S)-2,4-bis(tert-butyldimethylsilyloxy)heptyl]-4,6-dimethoxybenzoate
There total 8 articles about ethyl 2-[(2R,4S)-2,4-bis(tert-butyldimethylsilyloxy)heptyl]-4,6-dimethoxybenzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N,N-dimethyl-aniline;
In
neat (no solvent);
at 200 ℃;
for 48h;
Sealed tube;
DOI:10.1002/ejoc.201301708
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1H-imidazole / dichloromethane / 2 h / 0 °C
2.1: lithium; ammonia / tetrahydrofuran / 0.17 h / -78 °C
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C
3.2: 0.25 h / -78 °C
4.1: (2R,5S)-2-tert-butyl 3,5-dimethylimidazolidin-4-one trifluoroacetic acid salt; copper(II) trifluoroacetate hydrate name...; sodium persulfate; lithium chloride / acetonitrile; water / 10 °C
4.2: 0.17 h / 0 - 20 °C
4.3: 0.5 h / 20 °C
5.1: n-butyllithium / tetrahydrofuran; toluene / 0.75 h / -78 °C / Inert atmosphere
5.2: 0.5 h / -78 °C / Inert atmosphere
6.1: 2,6-dimethylpyridine / dichloromethane / 0.25 h / 0 °C
7.1: N,N-dimethyl-aniline / neat (no solvent) / 48 h / 200 °C / Sealed tube
With
1H-imidazole; 2,6-dimethylpyridine; sodium persulfate; n-butyllithium; oxalyl dichloride; (2R,5S)-2-tert-butyl 3,5-dimethylimidazolidin-4-one trifluoroacetic acid salt; ammonia; lithium; dimethyl sulfoxide; N,N-dimethyl-aniline; copper(II) trifluoroacetate hydrate name...; lithium chloride;
In
tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;
7.1: |Alder-Rickert Cycloaddition;
DOI:10.1002/ejoc.201301708
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium; ammonia / tetrahydrofuran / 0.17 h / -78 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C
2.2: 0.25 h / -78 °C
3.1: (2R,5S)-2-tert-butyl 3,5-dimethylimidazolidin-4-one trifluoroacetic acid salt; copper(II) trifluoroacetate hydrate name...; sodium persulfate; lithium chloride / acetonitrile; water / 10 °C
3.2: 0.17 h / 0 - 20 °C
3.3: 0.5 h / 20 °C
4.1: n-butyllithium / tetrahydrofuran; toluene / 0.75 h / -78 °C / Inert atmosphere
4.2: 0.5 h / -78 °C / Inert atmosphere
5.1: 2,6-dimethylpyridine / dichloromethane / 0.25 h / 0 °C
6.1: N,N-dimethyl-aniline / neat (no solvent) / 48 h / 200 °C / Sealed tube
With
2,6-dimethylpyridine; sodium persulfate; n-butyllithium; oxalyl dichloride; (2R,5S)-2-tert-butyl 3,5-dimethylimidazolidin-4-one trifluoroacetic acid salt; ammonia; lithium; dimethyl sulfoxide; N,N-dimethyl-aniline; copper(II) trifluoroacetate hydrate name...; lithium chloride;
In
tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;
6.1: |Alder-Rickert Cycloaddition;
DOI:10.1002/ejoc.201301708
