2,2-Bis-{4-[3-(4-tert-butyl-phenoxy)-propoxy]-benzyl}-N,N'-bis-(2-hydroxy-ethyl)-malonamide

Base Information

Chemical Name:2,2-Bis-{4-[3-(4-tert-butyl-phenoxy)-propoxy]-benzyl}-N,N'-bis-(2-hydroxy-ethyl)-malonamide
CAS No.:186612-41-9
Molecular Formula:C₄₇H₆₂N₂O₈
Molecular Weight:783.018
Hs Code.:

Synonyms:2,2-Bis-{4-[3-(4-tert-butyl-phenoxy)-propoxy]-benzyl}-N,N'-bis-(2-hydroxy-ethyl)-malonamide

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Chemical Property of 2,2-Bis-{4-[3-(4-tert-butyl-phenoxy)-propoxy]-benzyl}-N,N'-bis-(2-hydroxy-ethyl)-malonamide

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Technology Process of 2,2-Bis-{4-[3-(4-tert-butyl-phenoxy)-propoxy]-benzyl}-N,N'-bis-(2-hydroxy-ethyl)-malonamide

There total 7 articles about 2,2-Bis-{4-[3-(4-tert-butyl-phenoxy)-propoxy]-benzyl}-N,N'-bis-(2-hydroxy-ethyl)-malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 98-54-4
para-tert-butylphenol

: 186612-36-2
N,N'-bis(2-hydroxyethyl)-2,2-bis[4-(3-bromopropoxy)benzyl]-1,3-propanediamide

: 186612-41-9
2,2-Bis-{4-[3-(4-tert-butyl-phenoxy)-propoxy]-benzyl}-N,N'-bis-(2-hydroxy-ethyl)-malonamide

Guidance literature:: With potassium carbonate; In acetone; for 72h; Heating;
DOI:10.1021/jo970383s

Reference yield:

: 836-43-1
4-benzyloxybenzyl alcohol

: 186612-41-9
2,2-Bis-{4-[3-(4-tert-butyl-phenoxy)-propoxy]-benzyl}-N,N'-bis-(2-hydroxy-ethyl)-malonamide

Guidance literature:: Multi-step reaction with 7 steps

1: 64 percent / HBr / acetic acid / 0 °C

2: 74 percent / NaH / tetrahydrofuran / 2 h / Heating

3: 65 percent / aq. NaOH / ethanol / 24 h / 90 °C

4: 1.) oxalyl chloride / 1.) DMF, CH₂Cl₂, 0 deg C, 30 min, 2.) acetonitrile, 0 deg C, 30 min

5: 88 percent / H₂ / Pd/C / ethanol / 3 h / Ambient temperature

6: 78 percent / K₂CO₃ / acetone / 72 h / Heating

7: 60 percent / K₂CO₃ / acetone / 72 h / Heating

With sodium hydroxide; oxalyl dichloride; hydrogen bromide; hydrogen; sodium hydride; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetic acid; acetone;
DOI:10.1021/jo970383s

Reference yield:

: 5544-60-5
4-(benzyloxy)benzyl bromide

: 186612-41-9
2,2-Bis-{4-[3-(4-tert-butyl-phenoxy)-propoxy]-benzyl}-N,N'-bis-(2-hydroxy-ethyl)-malonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / NaH / tetrahydrofuran / 2 h / Heating

2: 65 percent / aq. NaOH / ethanol / 24 h / 90 °C

3: 1.) oxalyl chloride / 1.) DMF, CH₂Cl₂, 0 deg C, 30 min, 2.) acetonitrile, 0 deg C, 30 min

4: 88 percent / H₂ / Pd/C / ethanol / 3 h / Ambient temperature

5: 78 percent / K₂CO₃ / acetone / 72 h / Heating

6: 60 percent / K₂CO₃ / acetone / 72 h / Heating

With sodium hydroxide; oxalyl dichloride; hydrogen; sodium hydride; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetone;
DOI:10.1021/jo970383s