N,N'-bis(2-hydroxyethyl)-2,2-bis[4-(3-bromopropoxy)benzyl]-1,3-propanediamide

Base Information

Chemical Name:N,N'-bis(2-hydroxyethyl)-2,2-bis[4-(3-bromopropoxy)benzyl]-1,3-propanediamide
CAS No.:186612-36-2
Molecular Formula:C₂₇H₃₆Br₂N₂O₆
Molecular Weight:644.401
Hs Code.:

Synonyms:N,N'-bis(2-hydroxyethyl)-2,2-bis[4-(3-bromopropoxy)benzyl]-1,3-propanediamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N'-bis(2-hydroxyethyl)-2,2-bis[4-(3-bromopropoxy)benzyl]-1,3-propanediamide

Chemical Property:

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Technology Process of N,N'-bis(2-hydroxyethyl)-2,2-bis[4-(3-bromopropoxy)benzyl]-1,3-propanediamide

There total 6 articles about N,N'-bis(2-hydroxyethyl)-2,2-bis[4-(3-bromopropoxy)benzyl]-1,3-propanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 109-64-8
1,3-dibromo-propane

: 186612-31-7
N,N'-bis(2-hydroxyethyl)-2,2-bis(4-hydroxybenzyl)-1,3-propanediamide

: 186612-36-2
N,N'-bis(2-hydroxyethyl)-2,2-bis[4-(3-bromopropoxy)benzyl]-1,3-propanediamide

Guidance literature:: With potassium carbonate; In acetone; for 72h; Heating;
DOI:10.1021/jo970383s

Reference yield:

: 836-43-1
4-benzyloxybenzyl alcohol

: 186612-36-2
N,N'-bis(2-hydroxyethyl)-2,2-bis[4-(3-bromopropoxy)benzyl]-1,3-propanediamide

Guidance literature:: Multi-step reaction with 6 steps

1: 64 percent / HBr / acetic acid / 0 °C

2: 74 percent / NaH / tetrahydrofuran / 2 h / Heating

3: 65 percent / aq. NaOH / ethanol / 24 h / 90 °C

4: 1.) oxalyl chloride / 1.) DMF, CH₂Cl₂, 0 deg C, 30 min, 2.) acetonitrile, 0 deg C, 30 min

5: 88 percent / H₂ / Pd/C / ethanol / 3 h / Ambient temperature

6: 78 percent / K₂CO₃ / acetone / 72 h / Heating

With sodium hydroxide; oxalyl dichloride; hydrogen bromide; hydrogen; sodium hydride; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetic acid; acetone;
DOI:10.1021/jo970383s

Reference yield:

: 5544-60-5
4-(benzyloxy)benzyl bromide

: 186612-36-2
N,N'-bis(2-hydroxyethyl)-2,2-bis[4-(3-bromopropoxy)benzyl]-1,3-propanediamide

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / NaH / tetrahydrofuran / 2 h / Heating

2: 65 percent / aq. NaOH / ethanol / 24 h / 90 °C

3: 1.) oxalyl chloride / 1.) DMF, CH₂Cl₂, 0 deg C, 30 min, 2.) acetonitrile, 0 deg C, 30 min

4: 88 percent / H₂ / Pd/C / ethanol / 3 h / Ambient temperature

5: 78 percent / K₂CO₃ / acetone / 72 h / Heating

With sodium hydroxide; oxalyl dichloride; hydrogen; sodium hydride; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetone;
DOI:10.1021/jo970383s