N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-4-methyl-2-(methylsulfonyl)-1H-imidazole-5-carbohydrazide

Base Information

• Chemical Name: N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-4-methyl-2-(methylsulfonyl)-1H-imidazole-5-carbohydrazide
• CAS No.: 1094346-47-0
• Molecular Formula: C₂₁H₁₆Cl₂FN₅O₅S
• Molecular Weight: 540.359
• Mol file: 1094346-47-0.mol

Synonyms:N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-4-methyl-2-(methylsulfonyl)-1H-imidazole-5-carbohydrazide

Chemical Property of N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-4-methyl-2-(methylsulfonyl)-1H-imidazole-5-carbohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-4-methyl-2-(methylsulfonyl)-1H-imidazole-5-carbohydrazide

There total 12 articles about N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-4-methyl-2-(methylsulfonyl)-1H-imidazole-5-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-2-(methylsulfonyl)-1H-imidazole-5-carboxylic acid (1094346-45-8) + 2-{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide (1093987-89-3) → N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-4-methyl-2-(methylsulfonyl)-1H-imidazole-5-carbohydrazide (1094346-47-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; at 25 ℃; for 48h;

Reference yield:

3,5-dichlorobenzonitrile (6575-00-4) → N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-4-methyl-2-(methylsulfonyl)-1H-imidazole-5-carbohydrazide (1094346-47-0)

Guidance literature:

Multi-step reaction with 9 steps

1.1: N,N-dimethyl-formamide / 0 - 20 °C

1.2: 20 °C / Cooling with ice

2.1: 2,4,6-trimethyl-pyridine; lithium iodide / 8 h / 185 °C / Inert atmosphere

2.2: Cooling with ice

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 20 °C

3.3: 20 °C / Cooling with ice

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

4.2: 4 h / 0 - 20 °C

4.3: 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 - 60 °C

5.2: 0 °C

6.1: sodium dithionite; water / tetrahydrofuran / 1 h / 20 °C

7.1: tert.-butylnitrite; copper dichloride / acetonitrile / 0.25 h / 50 °C

8.1: hydrazine / ethanol / 2 h / Reflux

9.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 48 h / 25 °C

With 2,4,6-trimethyl-pyridine; tert.-butylnitrite; sodium dithionite; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; copper dichloride; lithium iodide; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

3-chloro-5-methoxybenzonitrile (473923-96-5) → N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-4-methyl-2-(methylsulfonyl)-1H-imidazole-5-carbohydrazide (1094346-47-0)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 2,4,6-trimethyl-pyridine; lithium iodide / 8 h / 185 °C / Inert atmosphere

1.2: Cooling with ice

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 20 °C

2.3: 20 °C / Cooling with ice

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 4 h / 0 - 20 °C

3.3: 20 °C

4.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 - 60 °C

4.2: 0 °C

5.1: sodium dithionite; water / tetrahydrofuran / 1 h / 20 °C

6.1: tert.-butylnitrite; copper dichloride / acetonitrile / 0.25 h / 50 °C

7.1: hydrazine / ethanol / 2 h / Reflux

8.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 48 h / 25 °C

With 2,4,6-trimethyl-pyridine; tert.-butylnitrite; sodium dithionite; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; copper dichloride; lithium iodide; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; mineral oil;

upstream raw materials:

3,5-dichlorobenzonitrile

3-chloro-5-methoxybenzonitrile

3-chloro-5-hydroxybenzonitrile

3-chloro-5-[(2,3-difluoro-6-nitrophenyl)oxy]benzonitrile

Downstream raw materials:

3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-2-(methylsulfonyl)-1H-imidazol-5-yl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile