tert-butyl 7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepane-4-carboxylate

Base Information

Chemical Name:tert-butyl 7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepane-4-carboxylate
CAS No.:1372186-69-0
Molecular Formula:C₂₄H₂₉Cl₂NO₅
Molecular Weight:482.404
Hs Code.:

Synonyms:tert-butyl 7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepane-4-carboxylate

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Chemical Property of tert-butyl 7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepane-4-carboxylate

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Technology Process of tert-butyl 7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepane-4-carboxylate

There total 11 articles about tert-butyl 7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepane-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1372186-68-9
4-benzyl-7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepane

: 1372186-69-0
tert-butyl 7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepane-4-carboxylate

Guidance literature:: 4-benzyl-7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepane; With carbonochloridic acid 1-chloro-ethyl ester; In acetonitrile; at 90 ℃; for 2.5h;

In methanol; at 80 ℃; for 1h;

di-tert-butyl dicarbonate; With triethylamine; In tetrahydrofuran; at 10 - 35 ℃; for 1.5h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: C₁₉H₂₁Cl₂NO₃

: 1372186-69-0
tert-butyl 7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepane-4-carboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 1.5h;
DOI:10.1016/j.bmc.2015.05.017

Reference yield:

: 1155558-39-6
1-(3,4-dichlorophenyl)-2-(4-methoxyphenoxy)ethanone

: 1372186-69-0
tert-butyl 7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepane-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

1.2: 1.17 h / -78 - 35 °C

2.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2.25 h / 0 - 35 °C

2.2: Cooling with ice

3.1: magnesium sulfate; triethylamine / methanol / 1.5 h / 10 - 35 °C

3.2: 1.67 h / 0 - 35 °C

4.1: triethylamine / tetrahydrofuran / 2.17 h / 0 - 35 °C

5.1: sodium t-butanolate / tetrahydrofuran / 16 h / 0 - 35 °C

6.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2.25 h / 0 - 35 °C

6.2: Cooling with ice

7.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 2.5 h / 90 °C

7.2: 1 h / 80 °C

7.3: 1.5 h / 10 - 35 °C

With aluminum (III) chloride; lithium aluminium tetrahydride; n-butyllithium; carbonochloridic acid 1-chloro-ethyl ester; magnesium sulfate; triethylamine; sodium t-butanolate; In tetrahydrofuran; methanol; diethyl ether; hexane; acetonitrile;