tert-butyl 7-(3,4-dichlorophenyl)-7-(hydroxymethyl)-1,4-oxazepane-4-carboxylate

Base Information

Chemical Name:tert-butyl 7-(3,4-dichlorophenyl)-7-(hydroxymethyl)-1,4-oxazepane-4-carboxylate
CAS No.:1372189-34-8
Molecular Formula:C₁₇H₂₃Cl₂NO₄
Molecular Weight:376.28
Hs Code.:

Synonyms:tert-butyl 7-(3,4-dichlorophenyl)-7-(hydroxymethyl)-1,4-oxazepane-4-carboxylate

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Chemical Property of tert-butyl 7-(3,4-dichlorophenyl)-7-(hydroxymethyl)-1,4-oxazepane-4-carboxylate

Chemical Property:

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Technology Process of tert-butyl 7-(3,4-dichlorophenyl)-7-(hydroxymethyl)-1,4-oxazepane-4-carboxylate

There total 10 articles about tert-butyl 7-(3,4-dichlorophenyl)-7-(hydroxymethyl)-1,4-oxazepane-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1372186-69-0
tert-butyl 7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepane-4-carboxylate

: 1372189-34-8
tert-butyl 7-(3,4-dichlorophenyl)-7-(hydroxymethyl)-1,4-oxazepane-4-carboxylate

Guidance literature:: With ammonium cerium (IV) nitrate; In water; acetonitrile; at 0 ℃; for 0.5h;
DOI:10.1016/j.bmc.2015.05.017

Reference yield:

: 1155558-39-6
1-(3,4-dichlorophenyl)-2-(4-methoxyphenoxy)ethanone

: 1372189-34-8
tert-butyl 7-(3,4-dichlorophenyl)-7-(hydroxymethyl)-1,4-oxazepane-4-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

1.2: 1.17 h / -78 - 35 °C

2.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2.25 h / 0 - 35 °C

2.2: Cooling with ice

3.1: magnesium sulfate; triethylamine / methanol / 1.5 h / 10 - 35 °C

3.2: 1.67 h / 0 - 35 °C

4.1: triethylamine / tetrahydrofuran / 2.17 h / 0 - 35 °C

5.1: sodium t-butanolate / tetrahydrofuran / 16 h / 0 - 35 °C

6.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2.25 h / 0 - 35 °C

6.2: Cooling with ice

7.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 2.5 h / 90 °C

7.2: 1 h / 80 °C

7.3: 1.5 h / 10 - 35 °C

8.1: water; ammonium cerium (IV) nitrate / acetonitrile / 0.5 h / 0 °C

With aluminum (III) chloride; lithium aluminium tetrahydride; n-butyllithium; ammonium cerium (IV) nitrate; carbonochloridic acid 1-chloro-ethyl ester; water; magnesium sulfate; triethylamine; sodium t-butanolate; In tetrahydrofuran; methanol; diethyl ether; hexane; acetonitrile;

Reference yield:

: 18282-59-2
4-bromo-1,2-dichlorobenzene

: 1372189-34-8
tert-butyl 7-(3,4-dichlorophenyl)-7-(hydroxymethyl)-1,4-oxazepane-4-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: iodine; magnesium / diethyl ether / 1 h / 35 °C

1.2: 1 h / -10 - 35 °C

1.3: 1 h / 10 - 35 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 1.17 h / -78 - 35 °C

3.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2.25 h / 0 - 35 °C

3.2: Cooling with ice

4.1: magnesium sulfate; triethylamine / methanol / 1.5 h / 10 - 35 °C

4.2: 1.67 h / 0 - 35 °C

5.1: triethylamine / tetrahydrofuran / 2.17 h / 0 - 35 °C

6.1: sodium t-butanolate / tetrahydrofuran / 16 h / 0 - 35 °C

7.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2.25 h / 0 - 35 °C

7.2: Cooling with ice

8.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 2.5 h / 90 °C

8.2: 1 h / 80 °C

8.3: 1.5 h / 10 - 35 °C

9.1: water; ammonium cerium (IV) nitrate / acetonitrile / 0.5 h / 0 °C

With aluminum (III) chloride; lithium aluminium tetrahydride; n-butyllithium; ammonium cerium (IV) nitrate; carbonochloridic acid 1-chloro-ethyl ester; water; iodine; magnesium sulfate; magnesium; triethylamine; sodium t-butanolate; In tetrahydrofuran; methanol; diethyl ether; hexane; acetonitrile;