2-(4-(5-amino-6-(3-(4-(((tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile

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Chemical Name:2-(4-(5-amino-6-(3-(4-(((tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile
CAS No.:1402389-48-3
Molecular Formula:C₂₈H₂₉N₇O₂
Molecular Weight:495.584
Hs Code.:

Synonyms:2-(4-(5-amino-6-(3-(4-(((tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile

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Chemical Property of 2-(4-(5-amino-6-(3-(4-(((tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile

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Technology Process of 2-(4-(5-amino-6-(3-(4-(((tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile

There total 17 articles about 2-(4-(5-amino-6-(3-(4-(((tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1402390-92-4
tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-[2-(1-cyano-1-methyl-ethyl)-4-pyridyl]pyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-tetrahydropyran-4-yl-carbamate

: 1402389-48-3
2-(4-(5-amino-6-(3-(4-(((tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile

Guidance literature:: tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-[2-(1-cyano-1-methyl-ethyl)-4-pyridyl]pyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-tetrahydropyran-4-yl-carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3.5h;

With water; potassium carbonate; In ethanol; at 20 ℃;

Reference yield:

: 81172-89-6
terephthalaldehyde mono(diethylacetal)

: 1402389-48-3
2-(4-(5-amino-6-(3-(4-(((tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: methanol / 1.37 h / 20 °C

2.1: sodium tetrahydroborate; methanol / 2 h / 20 - 27 °C

3.1: triethylamine / dichloromethane / 5 - 20 °C

4.1: hydroxylamine hydrochloride / water; tetrahydrofuran / 20 °C

5.1: N-chloro-succinimide / Isopropyl acetate / 0.75 h / 55 °C

6.1: triethylamine / dichloromethane / 20 °C

7.1: sodium carbonate / bis(tri-tert-butylphasphine)palladium dichloride / acetonitrile; water / 20 - 70 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

8.2: 20 °C

With methanol; sodium tetrahydroborate; N-chloro-succinimide; hydroxylamine hydrochloride; sodium carbonate; triethylamine; trifluoroacetic acid; bis(tri-tert-butylphasphine)palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; Isopropyl acetate; water; acetonitrile;

Reference yield:

: 1232423-55-0
tert-butyl N-(5-bromo-3-ethynyl-pyrazin-2-yl)-N-tert-butoxycarbonyl-carbamate

: 1402389-48-3
2-(4-(5-amino-6-(3-(4-(((tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 20 °C

2.1: sodium carbonate / bis(tri-tert-butylphasphine)palladium dichloride / acetonitrile; water / 20 - 70 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

3.2: 20 °C

With sodium carbonate; triethylamine; trifluoroacetic acid; bis(tri-tert-butylphasphine)palladium dichloride; In dichloromethane; water; acetonitrile;