tert-butyl ((1S,2R)-2-hydroxy-1-methyl-2-phenylethyl)-[3-(4-phenylcyclohexa-1,4-dienyl)-propyl] carbamate

Base Information

Chemical Name:tert-butyl ((1S,2R)-2-hydroxy-1-methyl-2-phenylethyl)-[3-(4-phenylcyclohexa-1,4-dienyl)-propyl] carbamate
CAS No.:936644-71-2
Molecular Formula:C₂₉H₃₇NO₃
Molecular Weight:447.618
Hs Code.:

Synonyms:tert-butyl ((1S,2R)-2-hydroxy-1-methyl-2-phenylethyl)-[3-(4-phenylcyclohexa-1,4-dienyl)-propyl] carbamate

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Chemical Property of tert-butyl ((1S,2R)-2-hydroxy-1-methyl-2-phenylethyl)-[3-(4-phenylcyclohexa-1,4-dienyl)-propyl] carbamate

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Technology Process of tert-butyl ((1S,2R)-2-hydroxy-1-methyl-2-phenylethyl)-[3-(4-phenylcyclohexa-1,4-dienyl)-propyl] carbamate

There total 3 articles about tert-butyl ((1S,2R)-2-hydroxy-1-methyl-2-phenylethyl)-[3-(4-phenylcyclohexa-1,4-dienyl)-propyl] carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 936644-53-0
tert-butyl (1R,2S)-1-(tert-butyldimethylsilyloxy)-1-phenylpropan-2-yl(pent-4-ynyl)carbamate

: 2288-18-8
2-phenyl-1,3-butadiene

: 936644-71-2
tert-butyl ((1S,2R)-2-hydroxy-1-methyl-2-phenylethyl)-[3-(4-phenylcyclohexa-1,4-dienyl)-propyl] carbamate

: C₂₉H₃₇NO₃

Guidance literature:: tert-butyl (1R,2S)-1-(tert-butyldimethylsilyloxy)-1-phenylpropan-2-yl(pent-4-ynyl)carbamate; 2-phenyl-1,3-butadiene; [Rh(cycloocta-1,5-diene)(naphthalene)]BF₄; In dichloromethane; at 20 ℃; for 2h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; Further stages. Title compound not separated from byproducts.;
DOI:10.1039/b700744b

Reference yield:

: 6051-52-1
2-phenylbut-3-en-2-ol

: 936644-71-2
tert-butyl ((1S,2R)-2-hydroxy-1-methyl-2-phenylethyl)-[3-(4-phenylcyclohexa-1,4-dienyl)-propyl] carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 33 percent / para-toluenesulphonic acid mono-hydrate / tetrahydrofuran / 60 °C

2.1: [Rh(cycloocta-1,5-diene)(naphthalene)]BF₄ / CH₂Cl₂ / 2 h / 20 °C

2.2: TBAF / tetrahydrofuran / 20 °C

With para-toluenesulphonic acid mono-hydrate; [Rh(cycloocta-1,5-diene)(naphthalene)]BF₄; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b700744b

Reference yield:

: 98-86-2
acetophenone

: 936644-71-2
tert-butyl ((1S,2R)-2-hydroxy-1-methyl-2-phenylethyl)-[3-(4-phenylcyclohexa-1,4-dienyl)-propyl] carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 61 percent / tetrahydrofuran / 1 h / Heating

2.1: 33 percent / para-toluenesulphonic acid mono-hydrate / tetrahydrofuran / 60 °C

3.1: [Rh(cycloocta-1,5-diene)(naphthalene)]BF₄ / CH₂Cl₂ / 2 h / 20 °C

3.2: TBAF / tetrahydrofuran / 20 °C

With para-toluenesulphonic acid mono-hydrate; [Rh(cycloocta-1,5-diene)(naphthalene)]BF₄; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b700744b