3-(2-chlorophenyl)propylmalonic acid diethyl ester

Base Information

• Chemical Name: 3-(2-chlorophenyl)propylmalonic acid diethyl ester
• CAS No.: 78573-27-0
• Molecular Formula: C₁₆H₂₁ClO₄
• Molecular Weight: 312.793
• Mol file: 78573-27-0.mol

Synonyms:3-(2-chlorophenyl)propylmalonic acid diethyl ester

Chemical Property of 3-(2-chlorophenyl)propylmalonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-chlorophenyl)propylmalonic acid diethyl ester

There total 3 articles about 3-(2-chlorophenyl)propylmalonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-chlorophenyl)-propanol (6282-87-7) → 3-(2-chlorophenyl)propylmalonic acid diethyl ester (78573-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂, pyridine

2: NaOEt / ethanol / Heating

With pyridine; thionyl chloride; sodium ethanolate; In ethanol;

DOI:10.1021/jo01058a019

Reference yield:

ethyl 3-(2-chlorophenyl)propanoate (30573-88-7) → 3-(2-chlorophenyl)propylmalonic acid diethyl ester (78573-27-0)

Guidance literature:

Multi-step reaction with 3 steps

1: LiAlH₄ / diethyl ether

2: SOCl₂, pyridine

3: NaOEt / ethanol / Heating

With pyridine; lithium aluminium tetrahydride; thionyl chloride; sodium ethanolate; In diethyl ether; ethanol;

DOI:10.1021/jo01058a019

Reference yield:

1-chloro-2-(3-chloro-propyl)-benzene (90347-04-9) + diethyl malonate (105-53-3) → 3-(2-chlorophenyl)propylmalonic acid diethyl ester (78573-27-0)

Guidance literature:

With sodium ethanolate; In ethanol; Heating;

DOI:10.1021/jo01058a019

upstream raw materials:

1-chloro-2-(3-chloro-propyl)-benzene

diethyl malonate

3-(2-chlorophenyl)-propanol

ethyl 3-(2-chlorophenyl)propanoate

Downstream raw materials:

1-butyl-2-chlorobenzene

5-(2-Chlor-phenyl)-valeriansaeure