N,N-bis(ethoxycarbonylmethyl)-2-(ethoxycarbonylmethoxy)-5-(β-chloroethanamido)benzylamine

Base Information

Chemical Name:N,N-bis(ethoxycarbonylmethyl)-2-(ethoxycarbonylmethoxy)-5-(β-chloroethanamido)benzylamine
CAS No.:308124-33-6
Molecular Formula:C₂₁H₂₉ClN₂O₈
Molecular Weight:472.923
Hs Code.:

Synonyms:N,N-bis(ethoxycarbonylmethyl)-2-(ethoxycarbonylmethoxy)-5-(β-chloroethanamido)benzylamine

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Chemical Property of N,N-bis(ethoxycarbonylmethyl)-2-(ethoxycarbonylmethoxy)-5-(β-chloroethanamido)benzylamine

Chemical Property:

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Technology Process of N,N-bis(ethoxycarbonylmethyl)-2-(ethoxycarbonylmethoxy)-5-(β-chloroethanamido)benzylamine

There total 6 articles about N,N-bis(ethoxycarbonylmethyl)-2-(ethoxycarbonylmethoxy)-5-(β-chloroethanamido)benzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 79-04-9
chloroacetyl chloride

: 308124-32-5
N,N-bis(ethoxycarbonylmethyl)-2-(ethoxycarbonylmethoxy)-5-aminobenzylamine

: 308124-33-6
N,N-bis(ethoxycarbonylmethyl)-2-(ethoxycarbonylmethoxy)-5-(β-chloroethanamido)benzylamine

Guidance literature:: With triethylamine; In diethyl ether; at -20 - 20 ℃;

Reference yield:

: 932-30-9
2-Hydroxybenzylamine

: 308124-33-6
N,N-bis(ethoxycarbonylmethyl)-2-(ethoxycarbonylmethoxy)-5-(β-chloroethanamido)benzylamine

Guidance literature:: Multi-step reaction with 5 steps

1: KI; Na₂HPO₄ / acetonitrile / Heating

2: 6.8 g / K₂CO₃; 3A molecular sieves / acetonitrile / 24 h / Heating

3: 72 percent / aq. HNO₃; AcOH

4: 94 percent / H₂ / Pd/C / ethanol / 2585.81 - 3102.97 Torr

5: 80 percent / Et₃N / diethyl ether / -20 - 20 °C

With disodium hydrogenphosphate; 3 A molecular sieve; hydrogen; nitric acid; potassium carbonate; acetic acid; triethylamine; potassium iodide; palladium on activated charcoal; In diethyl ether; ethanol; acetonitrile; 1: Alkylation / 2: Etherification / 3: Nitration / 4: Reduction / 5: Acylation;

Reference yield:

: 308124-51-8
N,N-bis(ethoxycarbonylmethyl)-2-hydroxybenzylamine

: 308124-33-6
N,N-bis(ethoxycarbonylmethyl)-2-(ethoxycarbonylmethoxy)-5-(β-chloroethanamido)benzylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 6.8 g / K₂CO₃; 3A molecular sieves / acetonitrile / 24 h / Heating

2: 72 percent / aq. HNO₃; AcOH

3: 94 percent / H₂ / Pd/C / ethanol / 2585.81 - 3102.97 Torr

4: 80 percent / Et₃N / diethyl ether / -20 - 20 °C

With 3 A molecular sieve; hydrogen; nitric acid; potassium carbonate; acetic acid; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol; acetonitrile; 1: Etherification / 2: Nitration / 3: Reduction / 4: Acylation;