4-(3,4-dimethoxyphenyl)-3-(pyrrol-1-yl)-1H-pyrrole-2-pyrrolidine carboxamide

Base Information

Chemical Name:4-(3,4-dimethoxyphenyl)-3-(pyrrol-1-yl)-1H-pyrrole-2-pyrrolidine carboxamide
CAS No.:679426-06-3
Molecular Formula:C₂₁H₂₃N₃O₃
Molecular Weight:365.432
Hs Code.:

Synonyms:4-(3,4-dimethoxyphenyl)-3-(pyrrol-1-yl)-1H-pyrrole-2-pyrrolidine carboxamide

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Chemical Property of 4-(3,4-dimethoxyphenyl)-3-(pyrrol-1-yl)-1H-pyrrole-2-pyrrolidine carboxamide

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Technology Process of 4-(3,4-dimethoxyphenyl)-3-(pyrrol-1-yl)-1H-pyrrole-2-pyrrolidine carboxamide

There total 6 articles about 4-(3,4-dimethoxyphenyl)-3-(pyrrol-1-yl)-1H-pyrrole-2-pyrrolidine carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 123-75-1
pyrrolidine

: 679426-04-1
methyl 4-(3,4-dimethoxyphenyl)-3-(pyrrol-1-yl)-1H-pyrrole-2-carboxylate

: 679426-06-3
4-(3,4-dimethoxyphenyl)-3-(pyrrol-1-yl)-1H-pyrrole-2-pyrrolidine carboxamide

Guidance literature:: Heating;
DOI:10.1016/j.bmc.2006.09.022

Reference yield:

: 679426-00-7
methyl 3-amino-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylate

: 679426-06-3
4-(3,4-dimethoxyphenyl)-3-(pyrrol-1-yl)-1H-pyrrole-2-pyrrolidine carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / 4-chloropyridine hydrochloride / dioxane / 100 °C

2: 69 percent / Heating

With 4-chlorpyridine hydrochloride; In 1,4-dioxane; 1: Clauson-Kaas reaction;
DOI:10.1016/j.bmc.2006.09.022

Reference yield:

: 93-17-4
3,4-dimethoxyphenylacetonitrile

: 679426-06-3
4-(3,4-dimethoxyphenyl)-3-(pyrrol-1-yl)-1H-pyrrole-2-pyrrolidine carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 83 percent / NaOMe / methanol / 2 h / Heating

2.1: 96 percent / glacial acetic acid / H₂O / pH 4

3.1: 35 percent / sodium acetate / methanol; H₂O / 48 h / 20 °C

4.1: 85 percent / sodium methoxide / methanol / 0.75 h / Heating

5.1: 4-chloropyridine hydrochloride / dioxane / 0.25 h / Heating

5.2: 72 percent / 4-chloropyridine hydrochloride / dioxane / 3.5 h / Heating

6.1: 55 percent / 15 h / Heating

With sodium methylate; sodium acetate; 4-chlorpyridine hydrochloride; acetic acid; In 1,4-dioxane; methanol; water;
DOI:10.1021/jm030961z