2-({[1-(methoxycarbonyl)-5,6,7,8-tetrahydro-2-naphthalenyl]amino}sulfonyl)benzoic acid

Base Information

Chemical Name:2-({[1-(methoxycarbonyl)-5,6,7,8-tetrahydro-2-naphthalenyl]amino}sulfonyl)benzoic acid
CAS No.:681247-06-3
Molecular Formula:C₁₉H₁₉NO₆S
Molecular Weight:389.429
Hs Code.:

Synonyms:2-({[1-(methoxycarbonyl)-5,6,7,8-tetrahydro-2-naphthalenyl]amino}sulfonyl)benzoic acid

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Chemical Property of 2-({[1-(methoxycarbonyl)-5,6,7,8-tetrahydro-2-naphthalenyl]amino}sulfonyl)benzoic acid

Chemical Property:

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Technology Process of 2-({[1-(methoxycarbonyl)-5,6,7,8-tetrahydro-2-naphthalenyl]amino}sulfonyl)benzoic acid

There total 7 articles about 2-({[1-(methoxycarbonyl)-5,6,7,8-tetrahydro-2-naphthalenyl]amino}sulfonyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 681247-05-2
methyl 2-({[2-(methoxycarbonyl)phenyl]sulfonyl}amino)-5,6,7,8-tetrahydro-1-naphthalenecarboxylate

: 681247-06-3
2-({[1-(methoxycarbonyl)-5,6,7,8-tetrahydro-2-naphthalenyl]amino}sulfonyl)benzoic acid

Guidance literature:: With lithium hydroxide; In methanol; water; at 60 ℃;
DOI:10.1021/jm0601001

Reference yield:

: 947-65-9
methyl 2-hydroxy-1-naphthoate

: 681247-06-3
2-({[1-(methoxycarbonyl)-5,6,7,8-tetrahydro-2-naphthalenyl]amino}sulfonyl)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / H₂ / Pd/C / methanol; H₂O / 2.5 h / 60 °C / 77572.2 Torr

2: pyridine / CH₂Cl₂ / -20 - 20 °C

3: 54.06 g / Cs₂CO₃; Pd(OAc)2; 4,5-bis-diphenylphosphanyl-9,9-dimethyl-9H-xanthene / dioxane / 4 h / 100 °C

4: 100 percent / aq. HCl / tetrahydrofuran / 1 h / 20 °C

5: pyridine / 20 °C

6: LiOH / methanol; H₂O / 60 °C

With pyridine; hydrogenchloride; palladium diacetate; lithium hydroxide; hydrogen; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; dichloromethane; water; 3: Buchwald reaction;
DOI:10.1021/jm0601001

Reference yield:

: 846540-87-2
2-trifluoromethanesulfonyloxy-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester

: 681247-06-3
2-({[1-(methoxycarbonyl)-5,6,7,8-tetrahydro-2-naphthalenyl]amino}sulfonyl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 54.06 g / Cs₂CO₃; Pd(OAc)2; 4,5-bis-diphenylphosphanyl-9,9-dimethyl-9H-xanthene / dioxane / 4 h / 100 °C

2: 100 percent / aq. HCl / tetrahydrofuran / 1 h / 20 °C

3: pyridine / 20 °C

4: LiOH / methanol; H₂O / 60 °C

With hydrogenchloride; palladium diacetate; lithium hydroxide; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; water; 1: Buchwald reaction;
DOI:10.1021/jm0601001