2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-pyridin-2-ylmethylisobutyramide

Base Information

Chemical Name:2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-pyridin-2-ylmethylisobutyramide
CAS No.:1365091-35-5
Molecular Formula:C₁₉H₁₉N₃O₃S
Molecular Weight:369.444
Hs Code.:

Synonyms:2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-pyridin-2-ylmethylisobutyramide

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Chemical Property of 2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-pyridin-2-ylmethylisobutyramide

Chemical Property:

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Technology Process of 2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-pyridin-2-ylmethylisobutyramide

There total 3 articles about 2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-pyridin-2-ylmethylisobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3731-51-9
2-(Aminomethyl)pyridine

: 1356089-38-7
2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-2-methylpropionic acid

: 1365091-35-5
2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-pyridin-2-ylmethylisobutyramide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2012.01.085

Reference yield:

: 32454-35-6
2-(4-bromophenyl)-2-methylpropionic acid

: 1365091-35-5
2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-pyridin-2-ylmethylisobutyramide

Guidance literature:: Multi-step reaction with 2 steps

1.1: phenyllithium / tetrahydrofuran; toluene / 0.08 h / -80 °C / Inert atmosphere

1.2: 0.33 h / Inert atmosphere

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 20 °C

With benzotriazol-1-ol; phenyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; toluene;
DOI:10.1016/j.bmcl.2012.01.085

Reference yield:

: C₁₀H₁₀O₄S^(2-)*2Li⁽¹⁺⁾

: 1365091-35-5
2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-pyridin-2-ylmethylisobutyramide

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / water; methanol / 20 °C

1.2: 1 h

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 20 °C

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; water;