4-[2-({3-[(2S)-2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethoxy]-2,3,5,6-tetrabromophenol

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Chemical Name:4-[2-({3-[(2S)-2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethoxy]-2,3,5,6-tetrabromophenol
CAS No.:915769-91-4
Molecular Formula:C₃₃H₃₆Br₄O₆Si
Molecular Weight:876.347
Hs Code.:

Synonyms:4-[2-({3-[(2S)-2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethoxy]-2,3,5,6-tetrabromophenol

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Chemical Property of 4-[2-({3-[(2S)-2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethoxy]-2,3,5,6-tetrabromophenol

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Technology Process of 4-[2-({3-[(2S)-2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethoxy]-2,3,5,6-tetrabromophenol

There total 15 articles about 4-[2-({3-[(2S)-2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethoxy]-2,3,5,6-tetrabromophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 915769-90-3
3-[(2S)-2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]-2-(dimethyl-{2-[2,3,5,6-tetrabromo-4-(tert-butyldimethylsilanyloxy)phenoxy]ethyl}silanyl)furan

: 915769-91-4
4-[2-({3-[(2S)-2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethoxy]-2,3,5,6-tetrabromophenol

Guidance literature:: With pyridine hydrogenfluoride; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1016/j.tet.2007.04.031

Reference yield:

: 169310-73-0
1-methoxy-4-((3-methylbut-3-en-1-yl)oxy)benzene

: 915769-91-4
4-[2-({3-[(2S)-2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethoxy]-2,3,5,6-tetrabromophenol

Guidance literature:: Multi-step reaction with 9 steps

1.1: 95 percent / K₂OsO₂(OH)4; K₂CO₃; DHQ₂PHAL / K₃Fe(CN)6 / 2-methyl-propan-2-ol; H₂O / 24 h / 0 °C

2.1: 90 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 48 h / 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

3.2: 84 percent / BF₃*Et₂O / tetrahydrofuran; hexane / 1 h / -78 °C

4.1: 100 percent / KH / dimethylformamide / 0.75 h / 0 °C

5.1: 86 percent / N-bromosuccinimide / dimethylformamide / 1 h / 0 °C

6.1: n-BuLi / tetrahydrofuran / 0.42 h / -78 °C

6.2: 88 percent / tetrahydrofuran / 0.42 h / -78 °C

7.1: 9-BBN / tetrahydrofuran / 3 h / 20 °C

7.2: 96 percent / aq. NaOH; aq. H₂O₂ / tetrahydrofuran / 0.5 h / 0 °C

8.1: 75 percent / diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 20 °C

9.1: 89 percent / HF*pyridine / tetrahydrofuran / 1 h / 0 °C

With dmap; N-Bromosuccinimide; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; potassium dioxotetrahydroxoosmate(VI); di-isopropyl azodicarboxylate; potassium hydride; potassium carbonate; pyridine hydrogenfluoride; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; triphenylphosphine; potassium hexacyanoferrate(III); In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1.1: Sharpless asymmetric dihydroxylation / 8.1: Mitsunobu coupling;
DOI:10.1016/j.tet.2007.04.031

Reference yield:

: 209118-78-5
(2S)-4-(4-methoxyphenoxy)-2-methylbutane-1,2-diol

: 915769-91-4
4-[2-({3-[(2S)-2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethoxy]-2,3,5,6-tetrabromophenol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 90 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 48 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

2.2: 84 percent / BF₃*Et₂O / tetrahydrofuran; hexane / 1 h / -78 °C

3.1: 100 percent / KH / dimethylformamide / 0.75 h / 0 °C

4.1: 86 percent / N-bromosuccinimide / dimethylformamide / 1 h / 0 °C

5.1: n-BuLi / tetrahydrofuran / 0.42 h / -78 °C

5.2: 88 percent / tetrahydrofuran / 0.42 h / -78 °C

6.1: 9-BBN / tetrahydrofuran / 3 h / 20 °C

6.2: 96 percent / aq. NaOH; aq. H₂O₂ / tetrahydrofuran / 0.5 h / 0 °C

7.1: 75 percent / diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 20 °C

8.1: 89 percent / HF*pyridine / tetrahydrofuran / 1 h / 0 °C

With dmap; N-Bromosuccinimide; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; di-isopropyl azodicarboxylate; potassium hydride; pyridine hydrogenfluoride; triethylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 7.1: Mitsunobu coupling;
DOI:10.1016/j.tet.2007.04.031