(2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl (2R,2'R)-bis{2-[(tert-butoxycarbonyl)amino]propanoate}

Base Information

Chemical Name:(2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl (2R,2'R)-bis{2-[(tert-butoxycarbonyl)amino]propanoate}
CAS No.:1229002-49-6
Molecular Formula:C₄₂H₄₆ClN₇O₁₀S
Molecular Weight:876.387
Hs Code.:

(2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl (2R,2'R)-bis{2-[(tert-butoxycarbonyl)amino]propanoate}

Synonyms:(2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl (2R,2'R)-bis{2-[(tert-butoxycarbonyl)amino]propanoate}

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Chemical Property of (2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl (2R,2'R)-bis{2-[(tert-butoxycarbonyl)amino]propanoate}

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Technology Process of (2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl (2R,2'R)-bis{2-[(tert-butoxycarbonyl)amino]propanoate}

There total 7 articles about (2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl (2R,2'R)-bis{2-[(tert-butoxycarbonyl)amino]propanoate} which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 3744-87-4,7764-95-6,15761-38-3
Boc-(R)-Ala

: 1107662-18-9
2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-4-(4-{[(2R)-2,3-dihydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile

: 1229002-49-6
(2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl (2R,2'R)-bis{2-[(tert-butoxycarbonyl)amino]propanoate}

Guidance literature:: Boc-(R)-Ala; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 0.0833333h;

2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-4-(4-{[(2R)-2,3-dihydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 22091-36-7
4-chloromethyl-2-(4-chlorophenyl)oxazole

: 1229002-49-6
(2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl (2R,2'R)-bis{2-[(tert-butoxycarbonyl)amino]propanoate}

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 h / 20 °C

2.1: hydrogenchloride; water / ethanol / Reflux

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.08 h

3.2: 2 h / 20 °C

With hydrogenchloride; dmap; water; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1229002-49-6
(2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl (2R,2'R)-bis{2-[(tert-butoxycarbonyl)amino]propanoate}

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 160 °C / Inert atmosphere

2.1: 4-methyl-morpholine / ethanol / 19 h / 20 °C / Reflux

3.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 h / 20 °C

4.1: hydrogenchloride; water / ethanol / Reflux

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.08 h

5.2: 2 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; dmap; water; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide;