(S)-2-amino-4-(4-(pyrrolidin-1-ium-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride

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Chemical Name:(S)-2-amino-4-(4-(pyrrolidin-1-ium-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride
CAS No.:1574469-00-3
Molecular Formula:C₁₄H₁₇N₅O
Molecular Weight:271.322
Hs Code.:

Synonyms:(S)-2-amino-4-(4-(pyrrolidin-1-ium-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-amino-4-(4-(pyrrolidin-1-ium-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride

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Technology Process of (S)-2-amino-4-(4-(pyrrolidin-1-ium-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride

There total 6 articles about (S)-2-amino-4-(4-(pyrrolidin-1-ium-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1574306-29-8
tert-butyl (S)-2-amino-4-(4-(1-(tert-butoxycarbonyl)pyrrolidine-2-carboxamido)phenyl)-1H-imidazole-1-carboxylate

: 1574469-00-3
(S)-2-amino-4-(4-(pyrrolidin-1-ium-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride

Guidance literature:: With acetyl chloride; In ethanol; at 0 ℃; for 1h;
DOI:10.1016/j.ejmech.2013.12.034

Reference yield:

: 99-81-0
4-Nitrophenacyl bromide

: 1574469-00-3
(S)-2-amino-4-(4-(pyrrolidin-1-ium-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap / acetonitrile / 5 h / 20 °C

2.1: hydrazine hydrate / ethyl [2]alcohol / 0.67 h / 120 °C / Microwave irradiation

3.1: methanol / 3 h / 20 °C

4.1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 5 h / 20 °C

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / dichloromethane / 0.5 h / 20 °C

5.2: 24 h / 35 °C

6.1: acetyl chloride / ethanol / 1 h / 0 °C

With 4-methyl-morpholine; dmap; palladium on activated charcoal; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; acetyl chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl [2]alcohol; acetonitrile;
DOI:10.1016/j.ejmech.2013.12.034

Reference yield:

: 1042275-05-7
2-hydroxy-2-(4-nitrophenyl)-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide

: 1574469-00-3
(S)-2-amino-4-(4-(pyrrolidin-1-ium-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / ethyl [2]alcohol / 0.67 h / 120 °C / Microwave irradiation

2.1: methanol / 3 h / 20 °C

3.1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 5 h / 20 °C

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / dichloromethane / 0.5 h / 20 °C

4.2: 24 h / 35 °C

5.1: acetyl chloride / ethanol / 1 h / 0 °C

With 4-methyl-morpholine; palladium on activated charcoal; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; acetyl chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl [2]alcohol;
DOI:10.1016/j.ejmech.2013.12.034