2-[4-(3-chloro-5-vinyl-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole

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Chemical Name:2-[4-(3-chloro-5-vinyl-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole
CAS No.:900184-35-2
Molecular Formula:C₂₆H₂₀ClF₆N₅
Molecular Weight:551.922
Hs Code.:

2-[4-(3-chloro-5-vinyl-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1<i>H</i>-benzoimidazole

Synonyms:2-[4-(3-chloro-5-vinyl-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole

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Chemical Property of 2-[4-(3-chloro-5-vinyl-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole

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Technology Process of 2-[4-(3-chloro-5-vinyl-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole

There total 9 articles about 2-[4-(3-chloro-5-vinyl-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 900184-18-1
2-[4-(5-bromo-3-chloro-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole

: 7486-35-3
tri-n-butyl(vinyl)tin

: 900184-35-2
2-[4-(3-chloro-5-vinyl-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butylphenol; lithium chloride; In 1,4-dioxane; at 95 ℃; for 5h;
DOI:10.1021/jm060065y

Reference yield:

: 75336-86-6
(2R)-methylpiperazine

: 900184-35-2
2-[4-(3-chloro-5-vinyl-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / iPr₂NEt / 1-methyl-pyrrolidin-2-one / 1 h / 240 °C / microwave irradiation

2: 71 percent / Br₂ / CH₂Cl₂ / 0.5 h / 20 °C

3: 34 percent / iPr₂NEt / ethanol / 4 h / 180 °C / microwave irradiation

4: 72 percent / Pd(PPh₃)4; LiCl; 2,6-di-tert-butylphenol / dioxane / 5 h / 95 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butylphenol; bromine; N-ethyl-N,N-diisopropylamine; lithium chloride; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane;
DOI:10.1021/jm060065y

Reference yield:

: 878810-10-7
(R)-1-(5-bromo-3-chloropyridin-2-yl)-3-methylpiperazine

: 900184-35-2
2-[4-(3-chloro-5-vinyl-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 34 percent / iPr₂NEt / ethanol / 4 h / 180 °C / microwave irradiation

2: 72 percent / Pd(PPh₃)4; LiCl; 2,6-di-tert-butylphenol / dioxane / 5 h / 95 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butylphenol; N-ethyl-N,N-diisopropylamine; lithium chloride; In 1,4-dioxane; ethanol;
DOI:10.1021/jm060065y