5-{[2-(1,4-dithiaspiro[4.5]dec-7-en-8-yl)ethylamino]methyl}-2-methoxyphenol

Base Information

Chemical Name:5-{[2-(1,4-dithiaspiro[4.5]dec-7-en-8-yl)ethylamino]methyl}-2-methoxyphenol
CAS No.:363132-87-0
Molecular Formula:C₁₈H₂₅NO₂S₂
Molecular Weight:351.534
Hs Code.:

Synonyms:5-{[2-(1,4-dithiaspiro[4.5]dec-7-en-8-yl)ethylamino]methyl}-2-methoxyphenol

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Chemical Property of 5-{[2-(1,4-dithiaspiro[4.5]dec-7-en-8-yl)ethylamino]methyl}-2-methoxyphenol

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Technology Process of 5-{[2-(1,4-dithiaspiro[4.5]dec-7-en-8-yl)ethylamino]methyl}-2-methoxyphenol

There total 3 articles about 5-{[2-(1,4-dithiaspiro[4.5]dec-7-en-8-yl)ethylamino]methyl}-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 363132-86-9
N-{2-(1,4-dithiaspiro[4.5]dec-7-en-8-yl)ethyl}-N-(3-hydroxy-4-methoxybenzyl)formamide

: 363132-87-0
5-{[2-(1,4-dithiaspiro[4.5]dec-7-en-8-yl)ethylamino]methyl}-2-methoxyphenol

Guidance literature:: With sodium hydroxide; at 110 ℃; for 20h;
DOI:10.1016/S0040-4020(01)00497-5

Reference yield:

: 363132-72-3
N-(3-hydroxy-4-methoxybenzyl)-N-[2-(4-methoxycyclohexa-1,4-dien-1-yl)ethyl]formamide

: 363132-87-0
5-{[2-(1,4-dithiaspiro[4.5]dec-7-en-8-yl)ethylamino]methyl}-2-methoxyphenol

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / aq. HCOOH / 20 °C

2: 76.3 percent / BF₃*OEt₂ / CH₂Cl₂ / 14 h / 20 °C

3: 56 percent / aq. NaOH / 20 h / 110 °C

With sodium hydroxide; formic acid; boron trifluoride diethyl etherate; In dichloromethane;
DOI:10.1016/S0040-4020(01)00497-5

Reference yield:

: 363132-77-8
N-(3-hydroxy-4-methoxybenzyl)-N-[2-(4-oxocyclohex-1-enyl)ethyl]formamide

: 363132-87-0
5-{[2-(1,4-dithiaspiro[4.5]dec-7-en-8-yl)ethylamino]methyl}-2-methoxyphenol

Guidance literature:: Multi-step reaction with 2 steps

1: 76.3 percent / BF₃*OEt₂ / CH₂Cl₂ / 14 h / 20 °C

2: 56 percent / aq. NaOH / 20 h / 110 °C

With sodium hydroxide; boron trifluoride diethyl etherate; In dichloromethane;
DOI:10.1016/S0040-4020(01)00497-5