Bis-PEG4-acid

Base Information

• Chemical Name: Bis-PEG4-acid
• CAS No.: 96517-92-9
• Molecular Formula: C₁₀H₁₈O₇
• Molecular Weight: 250.249
• Mol file: 96517-92-9.mol

Synonyms:3,3’-((oxybis(ethane-2,1-diyl))bis(oxy))dipropanoic acid

Chemical Property of Bis-PEG4-acid

Chemical Property:

• Boiling Point: 445.4±40.0 °C(Predicted)
• PKA: 3.97±0.10(Predicted)
• Density: 1.239±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Solubility.: Soluble in Water, DMSO, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

Bis-PEG3-acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Bis-PEG3-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Technology Process of Bis-PEG4-acid

There total 3 articles about Bis-PEG4-acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(2-(2-cyanoethoxy)ethyl)ether (22397-31-5) → 3,3’-((oxybis(ethane-2,1-diyl))bis(oxy))dipropanoic acid (96517-92-9)

Guidance literature:

With hydrogenchloride; at 70 - 100 ℃;

Reference yield:

di-tert-butyl 3,3’-((oxybis(ethane-2,1-diyl))bis(oxy))dipropanoate (1611468-29-1) → 3,3’-((oxybis(ethane-2,1-diyl))bis(oxy))dipropanoic acid (96517-92-9)

Guidance literature:

With formic acid; at 20 ℃;

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + bis(2-(2-cyanoethoxy)ethyl)ether (22397-31-5) → 3,3’-((oxybis(ethane-2,1-diyl))bis(oxy))dipropanoic acid (96517-92-9)

Guidance literature:

upstream raw materials:

bis(2-(2-cyanoethoxy)ethyl)ether

hydrogenchloride

di-tert-butyl 3,3’-((oxybis(ethane-2,1-diyl))bis(oxy))dipropanoate