22397-31-5

Basic information

• Product Name: 3,3'-[Oxybis(2,1-ethanediyloxy)]bispropanenitrile
• Synonyms: 3,3'-[Oxybis(2,1-ethanediyloxy)]bispropanenitrile;3,3'-((Oxybis(ethane-2,1-diyl))bis(oxy))dipropanenitrile
• CAS NO: 22397-31-5
• Molecular Formula: C₁₀H₁₆N₂O₃
• Molecular Weight: 212.24564
• Mol File: 22397-31-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 392.4°Cat760mmHg
• Flash Point: 161.8°C
• Appearance: /
• Density: 1.064g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3,3'-[Oxybis(2,1-ethanediyloxy)]bispropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3'-[Oxybis(2,1-ethanediyloxy)]bispropanenitrile(22397-31-5)
• EPA Substance Registry System: 3,3'-[Oxybis(2,1-ethanediyloxy)]bispropanenitrile(22397-31-5)

Safety Data

• Hazardous Substances Data: 22397-31-5(Hazardous Substances Data)

Usage

General Description

3,3'-[Oxybis(2,1-ethanediyloxy)]bispropanenitrile, also known as Bis(2-cyanoethyl) ether or Di(2-cyanoethyl) ether, is a chemical compound with the molecular formula C10H14N2O4. It is a colorless liquid with a faint odor and is commonly used as a crosslinking agent in polymer production. Bis(2-cyanoethyl) ether is also utilized as a solvent and intermediate in the manufacturing of pharmaceuticals, dyes, and rubber chemicals. It is considered to be a potential irritant to the skin, eyes, and respiratory system, and caution should be exercised when handling this chemical. Additionally, it is important to follow proper safety protocols and guidelines for its storage and disposal to prevent any potential harmful effects on human health and the environment.

Upstream product

• 542-76-7 3-Chloropropionitrile 
• 111-46-6 diethylene glycol 
• 107-13-1 acrylonitrile 

Downstream Products

• 10143-54-1 3-(2-(2-hydroxyethoxy)ethoxy)propanenitrile 
• 4246-51-9 4,7,10-trioxa-1,13-diaminotridecane 
• 112-33-4 2-[2-(3-amino-propoxy)-ethoxy]-ethanol 
• 111-46-6 diethylene glycol 
• 96517-92-9 3,3’-((oxybis(ethane-2,1-diyl))bis(oxy))dipropanoic acid 
• 6291-85-6 3-ethoxypropylamine 

Relevant articles and documents

BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY

The present invention relates to compounds of formula (I) useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Synthesis and intrinsic blue fluorescence study of hyperbranched poly(ester-amide-ether)

A series of hyperbranched poly(ester-amide-ether)s (H-PEAEs) were synthesized via the A2+CB3 approach by the self-transesterification of ethyl ester-amide-ethers end-capped with three hydroxyl groups and ethyl ester group at two terminals. The molecular structures were characterized with 1H NMR and FT-IR spectroscopy. The number average molecular weights were estimated by GPC analysis to possess bimodal wide distribution from 1.57 to 2.09. The strong inherent blue fluorescence was observed at 330 nm for excitation and 390 nm for emission. Moreover, the emission intensity and fluorescence quantum yield increased along with the incorporated ether chain length, as well as almost linearly with the H-PEAE concentration in an aqueous solution. For comparing the fluorescence performance, the linear poly(ester-amide-ether) (L-PEAE) and hyperbranched poly(ester-amide) (H-PEA) were synthesized. The results showed that the coexistence of ether bond and carboxyl group in the molecular chain was essential for generating the strong fluorescence. However, the compact backbone of H-PEAE would be propitious to the enhancement of fluorescence properties.

Intramolecular End-to-End Reactions of Photoactive Terminal Groups Linked by Poly(oxyethylene) Chains

The triplet-sensitized photochemical reaction using a series of poly(oxyethylene) chains with a pair of photoactive terminal groups, dibenzazepine (DBA) chromophores (DBA-COCH2CH2(OCH2CH2)nOCH2CH2CO-DBA, n=0-10) was examined.The photoirradiation of bichromophoric compounds caused either intra- or intermolecular reactions.These reactions were kinetically analyzed by two different methods: the measurement of deactivation processes of the reaction intermediates (excited triplet state of DBA) by nanosecond laser photolysis and the quantitative analysis of the reaction products by GPC.The intramolecular deactivation rate constant, kintra, showed a remarkable chain-length dependence; the maximum kintra value appeared at n=5 and it was found to be 5.9X104 s-1.On the other hand, the intramolecular cyclization rate also depends on the chain length; the maximum quantum yield, φintrad, was given at n=7 (φintrad=0.51).The chain length for the maximum cyclization yield shifted slightly to the longer region than that for the maximum kintra value due to the restriction of the terminal structure (anti-configuration).The results obtained for this reaction system are compared with those obtained for the previously reported polymethylene system and the effect of chain flexibility on the intramolecular ring-closure reaction is discussed.