(1'R)-phenyl-(2'S)-[(phenylmethyl)[(2,4,6-trimethylphenyl)sulfonyl]amino]-propyl (3R)-hydroxy-(2R),4-dimethylpentanoate

Base Information

Chemical Name:(1'R)-phenyl-(2'S)-[(phenylmethyl)[(2,4,6-trimethylphenyl)sulfonyl]amino]-propyl (3R)-hydroxy-(2R),4-dimethylpentanoate
CAS No.:187324-70-5
Molecular Formula:C₃₂H₄₁NO₅S
Molecular Weight:551.747
Hs Code.:

Synonyms:(1'R)-phenyl-(2'S)-[(phenylmethyl)[(2,4,6-trimethylphenyl)sulfonyl]amino]-propyl (3R)-hydroxy-(2R),4-dimethylpentanoate

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Chemical Property of (1'R)-phenyl-(2'S)-[(phenylmethyl)[(2,4,6-trimethylphenyl)sulfonyl]amino]-propyl (3R)-hydroxy-(2R),4-dimethylpentanoate

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Technology Process of (1'R)-phenyl-(2'S)-[(phenylmethyl)[(2,4,6-trimethylphenyl)sulfonyl]amino]-propyl (3R)-hydroxy-(2R),4-dimethylpentanoate

There total 10 articles about (1'R)-phenyl-(2'S)-[(phenylmethyl)[(2,4,6-trimethylphenyl)sulfonyl]amino]-propyl (3R)-hydroxy-(2R),4-dimethylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 78-84-2
isobutyraldehyde

: 187324-66-9
(1R,2S)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl propionate

: 187324-70-5
(1'R)-phenyl-(2'S)-[(phenylmethyl)[(2,4,6-trimethylphenyl)sulfonyl]amino]-propyl (3R)-hydroxy-(2R),4-dimethylpentanoate

Guidance literature:: (1R,2S)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl propionate; With triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In hexane; dichloromethane; at -78 ℃; for 2h;

isobutyraldehyde; In hexane; dichloromethane; at -78 - 20 ℃; for 2h; Further stages.;
DOI:10.1021/jo0257896

Reference yield:

: 492-41-1,58550-13-3,757124-50-8
(1R,2S)-norephedrine

: 187324-70-5
(1'R)-phenyl-(2'S)-[(phenylmethyl)[(2,4,6-trimethylphenyl)sulfonyl]amino]-propyl (3R)-hydroxy-(2R),4-dimethylpentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / triethylamine / CH₂Cl₂ / 2 h / 0 - 20 °C

2.1: 95 percent / potassium carbonate / acetonitrile / 7 h / Heating

3.1: 100 percent / pyridine / CH₂Cl₂ / 13 h / 20 °C

4.1: dicyclohexylboron triflate; triethylamine / CH₂Cl₂; hexane / 2 h / -78 °C

4.2: 98 percent / CH₂Cl₂; hexane / 2 h / -78 - 20 °C

With pyridine; potassium carbonate; triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In hexane; dichloromethane; acetonitrile;
DOI:10.1021/jo0257896

Reference yield:

: 108530-02-5
(1R,2S)-2-(N-mesitylenesulfonyl)amino-1-phenyl-1-propanol

: 187324-70-5
(1'R)-phenyl-(2'S)-[(phenylmethyl)[(2,4,6-trimethylphenyl)sulfonyl]amino]-propyl (3R)-hydroxy-(2R),4-dimethylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / potassium carbonate / acetonitrile / 7 h / Heating

2.1: 100 percent / pyridine / CH₂Cl₂ / 13 h / 20 °C

3.1: dicyclohexylboron triflate; triethylamine / CH₂Cl₂; hexane / 2 h / -78 °C

3.2: 98 percent / CH₂Cl₂; hexane / 2 h / -78 - 20 °C

With pyridine; potassium carbonate; triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In hexane; dichloromethane; acetonitrile;
DOI:10.1021/jo0257896