2S-(2α,5α,6α)-6-amino-3,3-dimethyl-6-<4-(methylphenyl)thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid 2,2,2-trichloroethyl ester

Base Information

• Chemical Name: 2S-(2α,5α,6α)-6-amino-3,3-dimethyl-6-<4-(methylphenyl)thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid 2,2,2-trichloroethyl ester
• CAS No.: 64278-72-4
• Molecular Formula: C₁₇H₁₉Cl₃N₂O₃S₂
• Molecular Weight: 469.84

Synonyms:2S-(2α,5α,6α)-6-amino-3,3-dimethyl-6-<4-(methylphenyl)thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid 2,2,2-trichloroethyl ester

Chemical Property of 2S-(2α,5α,6α)-6-amino-3,3-dimethyl-6-<4-(methylphenyl)thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid 2,2,2-trichloroethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2S-(2α,5α,6α)-6-amino-3,3-dimethyl-6-<4-(methylphenyl)thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid 2,2,2-trichloroethyl ester

There total 2 articles about 2S-(2α,5α,6α)-6-amino-3,3-dimethyl-6-<4-(methylphenyl)thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid 2,2,2-trichloroethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-aminopenicillanic acid trichloroethyl ester p-toluenesulfonate salt (30246-35-6) → 2S-(2α,5α,6α)-6-amino-3,3-dimethyl-6-<4-(methylphenyl)thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid 2,2,2-trichloroethyl ester (64278-72-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 80.4 percent / triethylamine, propylene oxide / CH₂Cl₂ / molecular sieves; 1.) 0 deg C, 2 h, 2.) 26 deg C, 0.5 h

2: 96 percent / triphenylphosphine / CH₂Cl₂ / 18 h / 26 °C / Mallinckrodt SilicAR CC-4

With triethylamine; triphenylphosphine; methyloxirane; In dichloromethane;

DOI:10.1021/ja00525a038

Reference yield:

→ 6β-Amino-6α-[(4-methylphenyl)thio]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 2,2,2-trichloroethyl ester (64278-72-4)

Guidance literature:

enspr. 6-(4-Methylphenylthioimino)-Verb., Triphenylphospin;

Reference yield: 27.0%

2S-(2α,5α,6α)-6-amino-3,3-dimethyl-6-<4-(methylphenyl)thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid 2,2,2-trichloroethyl ester (64278-72-4) + phenylacetyl chloride (103-80-0) → (2S,5R,6S)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-6-p-tolylsulfanyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2,2,2-trichloro-ethyl ester (64278-74-6)

Guidance literature:

With N,N-diethylaniline; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/ja00525a038

upstream raw materials:

6-aminopenicillanic acid trichloroethyl ester p-toluenesulfonate salt

Downstream raw materials:

(2S,5R,6S)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-6-p-tolylsulfanyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2,2,2-trichloro-ethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 64278-72-4 2S-(2α,5α,6α)-6-amino-3,3-dimethyl-6-<4-(methylphenyl)thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid 2,2,2-trichloroethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send