Technology Process of 21E-(4-methoxybenzylidene)-4-chloropregn-1,4-diene-3,20-dione
There total 3 articles about 21E-(4-methoxybenzylidene)-4-chloropregn-1,4-diene-3,20-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogenchloride / acetone / 1 h / Reflux
2: tert-butyldimethylsilyl chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 2 h / 0 °C / Reflux
3: potassium hydroxide / ethanol / 12 h / 20 °C
With
hydrogenchloride; tert-butyldimethylsilyl chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hydroxide;
In
1,4-dioxane; ethanol; acetone;
DOI:10.1016/j.steroids.2013.04.016
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tert-butyldimethylsilyl chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 2 h / 0 °C / Reflux
2: potassium hydroxide / ethanol / 12 h / 20 °C
With
tert-butyldimethylsilyl chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hydroxide;
In
1,4-dioxane; ethanol;
DOI:10.1016/j.steroids.2013.04.016
