(S)-2-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzylamino)ethanol hydrochloride

Base Information

Chemical Name:(S)-2-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzylamino)ethanol hydrochloride
CAS No.:1415694-93-7
Molecular Formula:C₂₅H₂₉N₇O*ClH
Molecular Weight:480.012
Hs Code.:

Synonyms:(S)-2-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzylamino)ethanol hydrochloride

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Chemical Property of (S)-2-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzylamino)ethanol hydrochloride

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Technology Process of (S)-2-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzylamino)ethanol hydrochloride

There total 6 articles about (S)-2-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzylamino)ethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1415695-26-9
2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamino)ethanol

: 1415695-25-8
(S)-6-Chloro-N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)-[1,2,4]-triazolo[1,5-a]pyridin-8-amine

: 1415694-93-7
(S)-2-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzylamino)ethanol hydrochloride

Guidance literature:: 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamino)ethanol; (S)-6-Chloro-N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)-[1,2,4]-triazolo[1,5-a]pyridin-8-amine; With caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; water; for 18h; Reflux; Inert atmosphere;

With hydrogenchloride; In water; pH=2;

Reference yield:

: 1415314-22-5
6-chloro-8-iodo-[1,2,4]triazolo[1,5-a]pyridine

: 1415694-93-7
(S)-2-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzylamino)ethanol hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / xylene / 8 h / 140 °C / Inert atmosphere

2.1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / Reflux; Inert atmosphere

2.2: pH 2

With caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; water; xylene;

Reference yield:

: 1072-98-6
5-chloro-2-pyridylamine

: 1415694-93-7
(S)-2-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzylamino)ethanol hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: iodine; silver sulfate / ethanol / 20 °C

2.1: isopropyl alcohol / 5 h / 100 °C

2.2: 16 h / 50 - 60 °C

3.1: trifluoroacetic anhydride / tetrahydrofuran / 16 h / 0 - 20 °C

4.1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / xylene / 8 h / 140 °C / Inert atmosphere

5.1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / Reflux; Inert atmosphere

5.2: pH 2

With iodine; caesium carbonate; silver sulfate; trifluoroacetic anhydride; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; water; isopropyl alcohol; xylene;