(Z)-5-methyl-2-(4-pentylbenzylidene)benzo[b]thiophen-3(2H)-one

Base Information

• Chemical Name: (Z)-5-methyl-2-(4-pentylbenzylidene)benzo[b]thiophen-3(2H)-one
• CAS No.: 1379675-28-1
• Molecular Formula: C₂₁H₂₂OS
• Molecular Weight: 322.471
• Mol file: 1379675-28-1.mol

Synonyms:(Z)-5-methyl-2-(4-pentylbenzylidene)benzo[b]thiophen-3(2H)-one

Chemical Property of (Z)-5-methyl-2-(4-pentylbenzylidene)benzo[b]thiophen-3(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (Z)-5-methyl-2-(4-pentylbenzylidene)benzo[b]thiophen-3(2H)-one

There total 4 articles about (Z)-5-methyl-2-(4-pentylbenzylidene)benzo[b]thiophen-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-pentylbenzaldehyde (6853-57-2) + 5-methylbenzothiophen-3(2H)-one (56639-88-4) → (Z)-5-methyl-2-(4-pentylbenzylidene)benzo[b]thiophen-3(2H)-one (1379675-28-1)

Guidance literature:

With piperidine; In benzene; for 2h; Reflux;

DOI:10.1002/anie.201108074

Reference yield:

(p-tolylthio)acetic acid chloride (30893-63-1) → (Z)-5-methyl-2-(4-pentylbenzylidene)benzo[b]thiophen-3(2H)-one (1379675-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / 1,2-dichloro-ethane / 1.03 h / 0 - 20 °C

2: piperidine / benzene / 2 h / Reflux

With piperidine; aluminum (III) chloride; In 1,2-dichloro-ethane; benzene;

DOI:10.1002/anie.201108074

Reference yield:

2-[(4-methylphenyl)thio]acetic acid (3996-29-0) → (Z)-5-methyl-2-(4-pentylbenzylidene)benzo[b]thiophen-3(2H)-one (1379675-28-1)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 1 h / Reflux

2: aluminum (III) chloride / 1,2-dichloro-ethane / 1.03 h / 0 - 20 °C

3: piperidine / benzene / 2 h / Reflux

With piperidine; aluminum (III) chloride; thionyl chloride; In 1,2-dichloro-ethane; benzene;

DOI:10.1002/anie.201108074

upstream raw materials:

(p-tolylthio)acetic acid chloride

4-pentylbenzaldehyde

5-methylbenzothiophen-3(2H)-one

2-[(4-methylphenyl)thio]acetic acid