3996-29-0

Usage

Uses

Used in Pharmaceutical Industry:
4-Methyl phenyl thioacetic acid is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to contribute to the development of new drugs with potential therapeutic properties.
Used in Agriculture Industry:
In the agricultural sector, 4-Methyl phenyl thioacetic acid is utilized as a precursor in the production of agrochemicals, contributing to the development of effective pesticides and other crop protection agents.
Used in Chemical Industry:
4-Methyl phenyl thioacetic acid is employed as a reagent in the chemical industry for the preparation of a wide range of organic compounds, showcasing its versatility in organic synthesis processes.

InChI:InChI=1/C9H10O2S/c1-7-2-4-8(5-3-7)12-6-9(10)11/h2-5H,6H2,1H3,(H,10,11)/p-1

Upstream product

• 109-72-8 n-butyllithium 
• 60-29-7 diethyl ether 
• 623-13-2 4-methylphenyl methylsulfide 
• 24197-66-8 S-chloroacetyl-p-mercaptotoluene 
• 14738-27-3 ethyl (p-tolylthio)acetate 
• 98111-37-6 p-tolylsulfanyl-thioacetic acid S-p-tolyl ester 
• 2943-42-2 di(4-methyl)phenylthiosulfonate 
• 141-52-6 sodium ethanolate 
• 141-97-9 ethyl acetoacetate 
• 79-11-8 chloroacetic acid 
• 5285-74-5 4-tolyl thiocyanate 
• 106-45-6 para-thiocresol 
• 105-56-6 ethyl 2-cyanoacetate 
• 105-53-3 diethyl malonate 

Downstream Products

• 30893-63-1 (p-tolylthio)acetic acid chloride 
• 52834-75-0 (p-tolylthio)methyl acetate 
• 3937-96-0 tosylacetic acid 
• 78440-59-2 3-p-tolylmercapto-coumarin 
• 35859-12-2 p-tolylsulfanyl-acetic acid 2-morpholin-4-yl-ethyl ester 
• 3996-42-7 2-[(4-methylphenyl)sulfinyl] acetic acid 
• 156001-91-1 N-<2-(p-tolylthio)ethanoyl>piperidine 
• 50397-67-6 methyl 2-(p-tolylthio)acetate 
• 102582-88-7 Tris(2-hydroxyethyl)ammonium 4-methylphenylthioacetate 
• 14738-27-3 ethyl (p-tolylthio)acetate 
• 156001-92-2 N-Hexyl-2-p-tolylsulfanyl-acetamide 
• 623-13-2 4-methylphenyl methylsulfide 
• 105892-16-8 p-Tolylsulfanyl-acetic acid; compound with 2-amino-ethanol 
• 91326-26-0 methyl 2,3-di(p-tolylsulfonyl)acetate 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of oxime lacking Psammaplin inspired chemical libraries as anti-cancer agents

In this study, we attempted the chemical simplification of Psammaplin (PsA), while retaining its activity in vitro. Inspired by the previous Structure Activity Relationship (SAR) studies on various PsA analogues and relying on the fact that oxime is metabolically unstable, we initially designed and synthesized a diverse library of PsA analogues and evaluated for cytotoxic activity. Among 32 compounds of Psammaplin analogues synthesized, the compound 10b was almost equally active as parent Psammaplin in vitro.

(Trifluoromethylselenyl)methylchalcogenyl as Emerging Fluorinated Groups: Synthesis under Photoredox Catalysis and Determination of the Lipophilicity

The synthesis of molecules bearing (trifluoromethylselenyl)methylchalcogenyl groups is described via an efficient two-step strategy based on a metal-free photoredox catalyzed decarboxylative trifluoromethylselenolation with good yields up to 88 %, which raised to 98 % in flow chemistry conditions. The flow methods allowed also to scale up the reaction. The mechanism of this key reaction was studied. The physicochemical characterization of these emerging groups was performed by determining their Hansch–Leo lipophilicity parameters with high values up to 2.24. This reaction was also extended to perfluoroalkylselenolation with yields up to 95 %. Finally, this method was successfully applied to the functionalization of relevant bioactive molecules such as tocopherol or estrone derivatives.

MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF

The disclosure relates to compounds and pharmaceutical compositions capable of modulating the hydroxysteroid 17-beta dehydrogenase (HSD17B) family member proteins including inhibiting the HSD17B member proteins, e.g. HSD17B13. The disclosure further relates to methods of treating liver diseases, disorders, or conditions with the compounds and pharmaceutical compositions disclosed herein, in which the HSD17B family member protein plays a role.

A highly stereoselective oxidation and an easy one pot elimination methodology for 3-allyl-3-phenylthio-β-lactams

A novel, facile, highly efficient and stereoselective protocol for the synthesis of cis-3-allyl-3-phenylsulfinyl-β-lactams and 3-allylidene-β-lactams from cis-3-allyl-3-phenylthio-β-lactams using Selectfluor both as an oxidizing agent and as an eliminating agent with temperature as a control parameter over the reaction outcome has been reported. The methodology is able to conquer the earlier reported shortcomings of long reaction time (24–90 hrs.) and lack of control over product ratio. The synthesized compounds will serve as important synthons for compounds of enhanced biological activity and potency.

RETRACTED ARTICLE: Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerases

A series of thiochromeno[2,3-c]quinolin-12-one derivatives with various substitutions were synthesized and evaluated as topoisomerase (Topo) inhibitors. Six (8, 10, 12, 14, 19, and 26) of 23 compounds showed strong inhibitory activities against Topo-media

Competitive behavior of nitrogen based axial ligands in the oxovanadium(IV)-salen catalyzed sulfoxidation of phenylmercaptoacetic acid

The sulfoxidation of twelve phenylmercaptoacetic acids (PMAA) by H2O2 catalyzed by three oxovanadium(IV)-salen complexes, having varied substituents on PMAA and salen with regard to their position, size and inductive effect, has been performed spectrophotometrically in 100percent acetonitrile medium. Three nitrogen bases (NB), pyridine (Py), imidazole (ImH) and 1-methylimidazole (MeIm), were used as axial ligands. It has been found that the rate of sulfoxidation is not only tuned by the substituents on PMAA and salen, but it is also varied by the addition of nitrogen bases. The observed order of retardation found among the different nitrogen bases is ImH > MeIm > Py. The rate of reaction decreases with the increase in concentration of the NB axial ligands. The strongly binding ImH shows the least reactivity. Hydroperoxovanadium(V)-salen has been proposed as the sole active oxidizing species. A detailed mechanistic study reveals that the low rate constant values in the presence of the nitrogen base is due to the existence of competition of NB with H2O2 and PMAA during the formation of active species and the coordination of PMAA with active species, respectively. Both electron donating and electron withdrawing substituents on PMAA retard the sulfoxidation rate significantly. The Hammett correlation between the rate constants and substituent constants shows a non-linear concave downward curve which is explained by the existence of two different rate determining steps within the same mechanism; coordination of PMAA with the active species for electron withdrawing substituents and transfer of oxygen to PMAA for electron donating substituents. All the experimental observations are explained by proposing a suitable mechanism.

Studies towards synthesis and Lewis acid catalysed functionalization of 3-(4′-substitutedphenylthio)-azetidin-2-ones

Abstract: Medicinal chemistry of heterocycles especially β-lactams have been an important discovery in today’s mankind. β-Lactam nucleus is structural feature and core of the biological activity of one of most successful classes of therapeutics to date ch

Integrated Synthesis of Thienyl Thioethers and Thieno[3,2-b]thiophenes via 1-Benzothiophen-3(2 H)-ones

A one-pot procedure for the synthesis of thienyl thioethers is described. Several thienyl thioethers were synthesized by a TfOH-promoted Friedel-Crafts-type cyclization, a subsequent nucleophilic attack by an arenethiol, and dehydration. This protocol was

Autolysis multi-functional liposome and application thereof

The invention relates to an autolysis multi-functional liposome and an application thereof. A preparation method comprises the steps of sequentially introducing a nitric oxide donor, polyethylene glycol and super paramagnetism ferroferric oxide nanoparticles to amino ends of distearoyl-phosphatidylethanolamine so as to obtain magnetic targeted phospholipid of a NO donor bridge chain. The magnetictargeted phospholipid of a NO donor bridge chain disclosed by the invention can be used as main components and cooperate with other auxiliary materials of distearoyl phosphatidylcholine, cholesterol and the like to prepare nanometer liposome. The liposome disclosed by the invention can be used for packing antitumor drugs of adriamycin and the like. The obtained drug delivery system is favorable instability under the physiological condition, and besides, under the condition of external magnetic field, the drug delivery system can be enriched in a magnetic field region, so that magnetism targeting can be realized; and the NO donor can split to release No molecules under the action of promotion factors of glutathione and the like, so that improvement of antineoplastic activity and overcomingof tumor drug tolerance are facilitated, the nanometer liposome can be disintegrated, and drugs are released and loaded. The drug release efficiency of the drug delivery system is improved, and the tumor treatment effect can be increased.

FMS-LIKE TYROSINE KINASE INHIBITORS

The present invention relates to Fms-like tyrosine kinase (FLT3) inhibitors. The present invention provides novel 4-quinolinone derivatives used as FLT3 inhibitors and for treatment and/or prevention of tumors.