(2S,4S,6R)-2-[2-(4-hydroxyphenyl)ethyl]-2-methoxy-6-tridecyltetrahydropyran-4-ol

Base Information

Chemical Name:(2S,4S,6R)-2-[2-(4-hydroxyphenyl)ethyl]-2-methoxy-6-tridecyltetrahydropyran-4-ol
CAS No.:945736-82-3
Molecular Formula:C₂₇H₄₆O₄
Molecular Weight:434.66
Hs Code.:

Synonyms:(2S,4S,6R)-2-[2-(4-hydroxyphenyl)ethyl]-2-methoxy-6-tridecyltetrahydropyran-4-ol

Suppliers and Price of (2S,4S,6R)-2-[2-(4-hydroxyphenyl)ethyl]-2-methoxy-6-tridecyltetrahydropyran-4-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S,6R)-2-[2-(4-hydroxyphenyl)ethyl]-2-methoxy-6-tridecyltetrahydropyran-4-ol

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Technology Process of (2S,4S,6R)-2-[2-(4-hydroxyphenyl)ethyl]-2-methoxy-6-tridecyltetrahydropyran-4-ol

There total 20 articles about (2S,4S,6R)-2-[2-(4-hydroxyphenyl)ethyl]-2-methoxy-6-tridecyltetrahydropyran-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 67-56-1
methanol

: (7R)-5-hydroxy-1-(4-hydroxy-phenyl)-7-(4-methoxy-benzyloxy)icosan-3-one

: 945736-82-3
(2S,4S,6R)-2-[2-(4-hydroxyphenyl)ethyl]-2-methoxy-6-tridecyltetrahydropyran-4-ol

Guidance literature:: With hydrogen; palladium dihydroxide; for 2h;
DOI:10.1021/jo0707986

Reference yield: 73.0%

: 67-56-1
methanol

: 945736-80-1
(2S,4S,6R)-2-[2-(4-hydroxyphenyl)ethyl]-6-tridecyltetrahydropyran-2,4-diol

: 945736-82-3
(2S,4S,6R)-2-[2-(4-hydroxyphenyl)ethyl]-2-methoxy-6-tridecyltetrahydropyran-4-ol

Guidance literature:: for 5h; Heating;
DOI:10.1021/jo0707986

Reference yield:

: 862472-84-2
(2E,5R)-octadec-2-en-5-ol

: 945736-82-3
(2S,4S,6R)-2-[2-(4-hydroxyphenyl)ethyl]-2-methoxy-6-tridecyltetrahydropyran-4-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 71 percent / imidazole / dimethylformamide / 20 - 100 °C

2.1: 4-methylmorpholine 4-oxide; osmium(VIII) oxide / H₂O; tetrahydrofuran / 2 h

2.2: 77 percent / AcOH; sodium metaperiodate / methanol; tetrahydrofuran; H₂O / 0.25 h

3.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.33 h / -78 °C

3.2: tetrahydrofuran / -78 - 20 °C

3.3: BF₃*OEt₂ / CH₂Cl₂ / 1.5 h

4.1: tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

5.1: 73 percent / 5 h / Heating

With 1H-imidazole; osmium(VIII) oxide; tetrabutyl ammonium fluoride; 4-methylmorpholine N-oxide; lithium diisopropyl amide; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; 3.3: Mukaiyama aldol reaction;
DOI:10.1021/jo0707986