2α-Ethoxy-9bα-hydroxy-1β-phenyl-1,2,3,9b-tetrahydro-5H-pyrrolo<2,1-α>isoindol-5-one

Base Information

• Chemical Name: 2α-Ethoxy-9bα-hydroxy-1β-phenyl-1,2,3,9b-tetrahydro-5H-pyrrolo<2,1-α>isoindol-5-one
• CAS No.: 78127-69-2
• Molecular Formula: C₁₉H₁₉NO₃
• Molecular Weight: 309.365
• Mol file: 78127-69-2.mol

Synonyms:2α-Ethoxy-9bα-hydroxy-1β-phenyl-1,2,3,9b-tetrahydro-5H-pyrrolo<2,1-α>isoindol-5-one

Chemical Property of 2α-Ethoxy-9bα-hydroxy-1β-phenyl-1,2,3,9b-tetrahydro-5H-pyrrolo<2,1-α>isoindol-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2α-Ethoxy-9bα-hydroxy-1β-phenyl-1,2,3,9b-tetrahydro-5H-pyrrolo<2,1-α>isoindol-5-one

There total 1 articles about 2α-Ethoxy-9bα-hydroxy-1β-phenyl-1,2,3,9b-tetrahydro-5H-pyrrolo<2,1-α>isoindol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

ethanol (64-17-5) + 2-[(E)-3-phenylprop-2-enyl]-2,3-dihydro-1H-isoindole-1,3-dione (17480-07-8) → 2α-Ethoxy-9bα-hydroxy-1β-phenyl-1,2,3,9b-tetrahydro-5H-pyrrolo<2,1-α>isoindol-5-one (78127-69-2) + 2β-Ethoxy-9bα-hydroxy-1α-phenyl-1,2,3,9b-tetrahydro-5H-pyrrolo<2,1-α>isoindol-5-one (78184-54-0)

Guidance literature:

for 5h; Irradiation;

DOI:10.1021/jo00331a007

Reference yield: 70.0%

2α-Ethoxy-9bα-hydroxy-1β-phenyl-1,2,3,9b-tetrahydro-5H-pyrrolo<2,1-α>isoindol-5-one (78127-69-2) + 2β-Ethoxy-9bα-hydroxy-1α-phenyl-1,2,3,9b-tetrahydro-5H-pyrrolo<2,1-α>isoindol-5-one (78184-54-0) → 2,3-Dihydro-2-ethoxy-1-phenyl-5H-pyrrolo<2,1-α>isoindol-5-one (78127-72-7)

Guidance literature:

With sodium acetate; In acetic anhydride; for 0.5h; Heating;

DOI:10.1021/jo00331a007

Reference yield:

2α-Ethoxy-9bα-hydroxy-1β-phenyl-1,2,3,9b-tetrahydro-5H-pyrrolo<2,1-α>isoindol-5-one (78127-69-2) → N-(2-Ethoxy-3-oxo-3-phenylpropyl)phthalimide (78127-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / CH₃CO₂Na / acetic anhydride / 0.5 h / Heating

2: 30 percent / CrO₃ / acetic acid / 2 h / Heating

With chromium(VI) oxide; sodium acetate; In acetic anhydride; acetic acid;

DOI:10.1021/jo00331a007

upstream raw materials:

ethanol

2-[(E)-3-phenylprop-2-enyl]-2,3-dihydro-1H-isoindole-1,3-dione

Downstream raw materials:

2,3-Dihydro-2-ethoxy-1-phenyl-5H-pyrrolo<2,1-α>isoindol-5-one

N-(2-Ethoxy-3-oxo-3-phenylpropyl)phthalimide