1H-Isoindole-1,3(2H)-dione, 2-(3-phenyl-2-propenyl)-, (E)-

Base Information

• Chemical Name: 1H-Isoindole-1,3(2H)-dione, 2-(3-phenyl-2-propenyl)-, (E)-
• CAS No.: 17480-07-8
• Molecular Formula: C17H13NO2
• Molecular Weight: 263.296
• Mol file: 17480-07-8.mol

Synonyms:2-(3-phenylprop-2-enyl)-1H-isoindole-1,3(2H)-dione;(E)-1-phenyl-3-phthalimido-2-propene;(E)-N-(3-phenyl-2-propenyl)phthalimide;2-[(2E)-3-phenylprop-2-en-1-yl]-1H-isoindole-1,3(2H)-dione;2-((E)-3-Phenyl-allyl)-isoindole-1,3-dione;2-[(2E)-3-phenylprop-2-enyl]-1H-isoindole-1,3(2H)-dione;2-[(E)-3-phenylallyl]-isoindole-1,3-dione;

Chemical Property of 1H-Isoindole-1,3(2H)-dione, 2-(3-phenyl-2-propenyl)-, (E)-

Chemical Property:

• Melting Point: 154.5 - 155 °C
• Boiling Point: 437.4±34.0 °C(Predicted)
• PSA: 37.38000
• Density: 1.259±0.06 g/cm3(Predicted)
• LogP: 2.93390

Purity/Quality:

99% ^*data from raw suppliers

2-[(E)-3-phenylprop-2-enyl]isoindole-1,3-dione 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Isoindole-1,3(2H)-dione, 2-(3-phenyl-2-propenyl)-, (E)-

There total 24 articles about 1H-Isoindole-1,3(2H)-dione, 2-(3-phenyl-2-propenyl)-, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

potassium phtalimide (1074-82-4) + cinnamyl chloride (2687-12-9) → 2-[(E)-3-phenylprop-2-enyl]-2,3-dihydro-1H-isoindole-1,3-dione (17480-07-8)

Guidance literature:

potassium iodide; In N,N-dimethyl-formamide; at 85 - 90 ℃; for 8h;

DOI:10.1021/jo00033a036

Reference yield: 93.0%

3-phthalimido-1-propene (5428-09-1) + iodobenzene (591-50-4) → 2-[(E)-3-phenylprop-2-enyl]-2,3-dihydro-1H-isoindole-1,3-dione (17480-07-8)

Guidance literature:

With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; at 110 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jacs.6b03596

Reference yield: 91.0%

3-phthalimido-1-propene (5428-09-1) + benzoic acid hydrazide (613-94-5) → 2-[(E)-3-phenylprop-2-enyl]-2,3-dihydro-1H-isoindole-1,3-dione (17480-07-8)

Guidance literature:

benzoic acid hydrazide; With copper(l) iodide; toluene-4-sulfonic acid; palladium dichloride; In dimethyl sulfoxide; acetonitrile; at 20 ℃; for 1h; under 760.051 Torr;

3-phthalimido-1-propene; In dimethyl sulfoxide; acetonitrile; at 100 ℃; for 3h; stereoselective reaction;

DOI:10.1002/chem.201304696

upstream raw materials:

trans-3-phenylprop-2-enyl chloride

potassium phtalimide

cinnamyl chloride

phthalimide

Downstream raw materials:

2-(3-phenylpropyl)-1H-isoindole-1,3(2H)-dione

(E)-cinnamylamine

2α-Ethoxy-9bα-hydroxy-1β-phenyl-1,2,3,9b-tetrahydro-5H-pyrrolo<2,1-α>isoindol-5-one

2β-Ethoxy-9bα-hydroxy-1α-phenyl-1,2,3,9b-tetrahydro-5H-pyrrolo<2,1-α>isoindol-5-one