tert-butyl[2-(3-methoxy-4-nitrophenoxy)ethoxy]dimethylsilane

Base Information

• Chemical Name: tert-butyl[2-(3-methoxy-4-nitrophenoxy)ethoxy]dimethylsilane
• CAS No.: 1309685-88-8
• Molecular Formula: C₁₅H₂₅NO₅Si
• Molecular Weight: 327.453
• Mol file: 1309685-88-8.mol

Synonyms:tert-butyl[2-(3-methoxy-4-nitrophenoxy)ethoxy]dimethylsilane

Chemical Property of tert-butyl[2-(3-methoxy-4-nitrophenoxy)ethoxy]dimethylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl[2-(3-methoxy-4-nitrophenoxy)ethoxy]dimethylsilane

There total 1 articles about tert-butyl[2-(3-methoxy-4-nitrophenoxy)ethoxy]dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

4-nitro-3-methoxyphenol (16292-95-8) + 2-(tert-butyldimethylsilyloxy)ethyl bromide (86864-60-0) → tert-butyl[2-(3-methoxy-4-nitrophenoxy)ethoxy]dimethylsilane (1309685-88-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 20h;

Reference yield: 99.0%

tert-butyl[2-(3-methoxy-4-nitrophenoxy)ethoxy]dimethylsilane (1309685-88-8) → 4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-2-methoxyphenylamine (1309685-87-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 0.5h; under 2585.81 Torr;

Reference yield: 81.0%

tert-butyl[2-(3-methoxy-4-nitrophenoxy)ethoxy]dimethylsilane (1309685-88-8) → 2-(3-methoxy-4-nitrophenoxy)ethanol (1258492-35-1)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 1h;

upstream raw materials:

4-nitro-3-methoxyphenol

2-(tert-butyldimethylsilyloxy)ethyl bromide

Downstream raw materials:

4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-2-methoxyphenylamine

(2'R,3'S,4'R,5'S)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [4-(2-hydroxy-ethoxy)-2-methoxy-phenyl]amide

(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [4-(2-hydroxyethoxy)-2-methoxyphenyl]amide

(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [4-(2-hydroxy-ethoxy)-2-methoxy-phenyl]-amide