(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [4-(2-hydroxy-ethoxy)-2-methoxy-phenyl]-amide

Base Information

Chemical Name:(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [4-(2-hydroxy-ethoxy)-2-methoxy-phenyl]-amide
CAS No.:1345866-74-1
Molecular Formula:C₃₂H₃₄Cl₂FN₃O₅
Molecular Weight:630.543
Hs Code.:

(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [4-(2-hydroxy-ethoxy)-2-methoxy-phenyl]-amide

Synonyms:(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [4-(2-hydroxy-ethoxy)-2-methoxy-phenyl]-amide

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Chemical Property of (2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [4-(2-hydroxy-ethoxy)-2-methoxy-phenyl]-amide

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Technology Process of (2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [4-(2-hydroxy-ethoxy)-2-methoxy-phenyl]-amide

There total 9 articles about (2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [4-(2-hydroxy-ethoxy)-2-methoxy-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1303606-45-2
(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid tert-butyl ester

: 1309685-87-7
4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-2-methoxyphenylamine

: 1345866-74-1
(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [4-(2-hydroxy-ethoxy)-2-methoxy-phenyl]-amide

Guidance literature:: (2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid tert-butyl ester; With N-ethyl-N,N-diisopropylamine; Diphenylphosphinic chloride; In dichloromethane; at 20 ℃; for 0.133333h;

4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-2-methoxyphenylamine; In dichloromethane; at 20 ℃; for 18h;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 1h;

Reference yield:

: 897365-76-3
(3E/Z)-6-chloro-3-(3-chloro-2-fluorobenzylidene)-1,3-dihydro-2H-indol-2-one

: 1345866-74-1
(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [4-(2-hydroxy-ethoxy)-2-methoxy-phenyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 18 h / 80 °C

2.1: hydrogen / palladium dichloride / tetrahydrofuran; methanol / 18 h / 3102.97 Torr

2.2: 0.17 h / 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 20 °C

3.2: 20 °C / pH 5 - 6

4.1: N-ethyl-N,N-diisopropylamine; Diphenylphosphinic chloride / dichloromethane / 0.13 h / 20 °C

4.2: 18 h / 20 °C

4.3: 1 h / 20 °C

With water; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; Diphenylphosphinic chloride; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 448-19-1
4-fluoro-2-methoxy-1-nitrobenzene

: 1345866-74-1
(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [4-(2-hydroxy-ethoxy)-2-methoxy-phenyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water; dimethyl sulfoxide / 20 h / 80 °C

1.2: pH 5

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 70 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 0.5 h / 2585.81 Torr

4.1: N-ethyl-N,N-diisopropylamine; Diphenylphosphinic chloride / dichloromethane / 0.13 h / 20 °C

4.2: 18 h / 20 °C

4.3: 1 h / 20 °C

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; Diphenylphosphinic chloride; palladium 10% on activated carbon; In dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;