methyl 2-[({2'-[1-benzyl-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-nitrobenzoate

Base Information

Chemical Name:methyl 2-[({2'-[1-benzyl-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-nitrobenzoate
CAS No.:1215298-30-8
Molecular Formula:C₂₉H₂₄N₆O₄
Molecular Weight:520.547
Hs Code.:

Synonyms:methyl 2-[({2'-[1-benzyl-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-nitrobenzoate

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Chemical Property of methyl 2-[({2'-[1-benzyl-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-nitrobenzoate

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Technology Process of methyl 2-[({2'-[1-benzyl-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-nitrobenzoate

There total 15 articles about methyl 2-[({2'-[1-benzyl-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28386-90-5
5-benzyl-1-phenyl-1H-tetrazole

: 1215298-30-8
methyl 2-[({2'-[1-benzyl-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-nitrobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 5 h / 140 °C / Inert atmosphere

2: sodium methylate / methanol / 18 - 20 °C

3: phosphorus tribromide / tetrahydrofuran / -9 - 12 °C

4: potassium carbonate / acetonitrile / 9 h / Reflux; Inert atmosphere

5: hydrogenchloride / methanol / 20 °C / Cooling with ice

With hydrogenchloride; sodium methylate; phosphorus tribromide; potassium carbonate; triphenylphosphine; dichloro(1,5-cyclooctadiene)ruthenium(II) polymer; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; acetonitrile;

Reference yield:

: 100-46-9
benzylamine

: 1215298-30-8
methyl 2-[({2'-[1-benzyl-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-nitrobenzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / tetrahydrofuran / 2 - 35 °C

2.1: phosphorus pentachloride / dichloromethane / -15 - 21 °C

2.2: 4.5 h / -8 - 20 °C

3.1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 5 h / 140 °C / Inert atmosphere

4.1: sodium methylate / methanol / 18 - 20 °C

5.1: phosphorus tribromide / tetrahydrofuran / -9 - 12 °C

6.1: potassium carbonate / acetonitrile / 9 h / Reflux; Inert atmosphere

7.1: hydrogenchloride / methanol / 20 °C / Cooling with ice

With hydrogenchloride; phosphorus pentachloride; sodium methylate; phosphorus tribromide; potassium carbonate; triethylamine; triphenylphosphine; dichloro(1,5-cyclooctadiene)ruthenium(II) polymer; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; acetonitrile;

Reference yield:

: 98-88-4
benzoyl chloride

: 1215298-30-8
methyl 2-[({2'-[1-benzyl-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-nitrobenzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / tetrahydrofuran / 2 - 35 °C

2.1: phosphorus pentachloride / dichloromethane / -15 - 21 °C

2.2: 4.5 h / -8 - 20 °C

3.1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 5 h / 140 °C / Inert atmosphere

4.1: sodium methylate / methanol / 18 - 20 °C

5.1: phosphorus tribromide / tetrahydrofuran / -9 - 12 °C

6.1: potassium carbonate / acetonitrile / 9 h / Reflux; Inert atmosphere

7.1: hydrogenchloride / methanol / 20 °C / Cooling with ice

With hydrogenchloride; phosphorus pentachloride; sodium methylate; phosphorus tribromide; potassium carbonate; triethylamine; triphenylphosphine; dichloro(1,5-cyclooctadiene)ruthenium(II) polymer; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; acetonitrile;