28386-90-5

Usage

Uses

Used in Corrosion Inhibition:
1-benzyl-5-phenyl-1H-tetrazole is used as a corrosion inhibitor for metals, leveraging its ability to form protective films on metal surfaces, thereby reducing the rate of corrosion and extending the service life of metal components.
Used in Organic Synthesis:
As a precursor in organic synthesis, 1-benzyl-5-phenyl-1H-tetrazole is utilized for the creation of other organic compounds, contributing to the development of new chemical entities with potential applications in various industries.
Used in Pharmaceutical Development:
1-benzyl-5-phenyl-1H-tetrazole is explored for its potential as an antihypertensive and antithrombotic agent, indicating its possible use in the development of medications for the treatment of high blood pressure and blood clotting disorders.
Used in Polymer Synthesis:
In the field of polymer materials, 1-benzyl-5-phenyl-1H-tetrazole is considered for its potential use in the synthesis of polymers, which could have applications in coatings, adhesives, and other materials science areas.
Used in Organic Light-Emitting Devices (OLEDs):
1-benzyl-5-phenyl-1H-tetrazole is also being investigated for its potential use as a component in organic light-emitting devices, where it could contribute to the development of more efficient and longer-lasting OLED technologies.

Upstream product

• 18039-42-4 5-Phenyl-1H-tetrazole 
• 5532-86-5 benzyl cyanoformate 
• 79344-08-4 1-benzyl-5-bromo-1H-tetrazole 
• 98-80-6 phenylboronic acid 
• 14309-89-8 N-benzyl-benzenecarbothioamide 
• 100-44-7 benzyl chloride 
• 100-46-9 benzylamine 
• 93-58-3 benzoic acid methyl ester 
• 100-39-0 benzyl bromide 
• 100-47-0 benzonitrile 
• 622-79-7 benzyl azide 
• 98-88-4 benzoyl chloride 
• 29814-09-3 sodium salt of 5-phenyltetrazole 
• 74305-28-5 ((CH₃(CH₂)3)3P)Co(HONC(CH₃)C(CH₃)NO)2(N₄C(C₆H₅)) 

Downstream Products

• 1215298-35-3 methyl 2-ethoxy-1-({2′-[1-(phenylmethyl)-1H-tetrazol-5-yl][1,1′-biphenyl]-4-yl}methyl)-1H-benzimidazole-7-carboxylate 
• 1307853-85-5 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 1-({4-[2-(1-benzyl-1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-2-ethoxy-1H-1,3-benzodiazole-7-carboxylate 
• 1307853-80-0 methyl 2-(N-tert-butoxycarbonyl-N-{(2'-[1-benzyl-1H-tetrazol-5-yl]biphenyl-4-yl)methyl}amino)-3-nitrobenzoate 
• 1215298-30-8 methyl 2-[({2'-[1-benzyl-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-nitrobenzoate 
• 1307853-81-1 methyl 2-[({2'-[1-benzyl-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-aminobenzoate 
• 1361119-71-2 5-phenyl-2-(o-tolyl)-2H-tetrazole 
• 36215-63-1 2-(naphthalen-2-yl)-5-phenyl-2H-tetrazole 
• 1186394-26-2 N-(4-(5-phenyl-2H-tetrazol-2-yl)phenyl)acetamide 
• 18039-45-7 2,5-diphenyl-2H-tetrazole 
• 1432044-40-0 1-benzyl-5-(3',4',5'-trimethoxy-[1,1'-biphenyl]-2-yl)-1H-tetrazole 

Relevant academic research and scientific papers

Synthesis of 5-Aryl and Vinyl Tetrazoles by the Palladium-Catalyzed Cross-Coupling Reaction

A coupling reaction of 1-benzyl-5-bromotetrazole with various aryl and vinyl boronic acids via the Suzuki type reaction is found to be a general and efficient reaction for the synthesis of aryl and vinyl tetrazoles.

An Expeditious Approach to Tetrazoles from Amides Utilizing Phosphorazidates

A novel method was developed for the synthesis of tetrazoles from amides utilizing diphenyl phosphorazidate or bis(p-nitrophenyl) phosphorazidate as both the activator of amide-oxygen for elimination and azide source. Various amides were converted into th

One-Pot Suzuki-Hydrogenolysis Protocol for the Modular Synthesis of 2,5-Diaryltetrazoles

2,5-Diaryltetrazoles are a diverse range of compounds of considerable interest within the field of photochemistry as a valuable precursor of the nitrile imine 1,3-dipole. Current literature approaches toward this heterocycle remain unsuitable for the prac

Iron (III)-porphyrin Complex FeTSPP as an efficient catalyst for synthesis of tetrazole derivatives via [2?+?3]cycloaddition reaction in aqueous medium

The metal complex (5,10,15,20-tetrakis-(4-sulfonatophenyl)-porphyrin-iron (III) chloride (FeTSPP) was new employed in an environmentally benign protocol as an efficient catalyst for a “click” chemistry approach for the synthesis of tetrazole and guanindinyltetrazole derivatives via [2?+?3] cycloaddition reaction of nitriles and azide derivatives in aqueous medium. The synthesized compounds were obtained in excellent yield, short reaction times and a recoverable catalyst.

Indium-, Magnesium-, and Zinc-Mediated Debenzylation of Protected 1 H -Tetrazoles: A Comparative Study

5-Substituted 1-benzyltetrazoles are easily debenzylated to give the corresponding deprotected tetrazoles using dissolved metals under protic conditions: Mg/MeOH, In/MeOH, or Zn/MeCO 2 H are the procedures of choice for this transformation.

Convergent Three-Component Tetrazole Synthesis

A microwave-accelerated, simple, and efficient method for the construction of the 1,5-tetrazole scaffold was developed. It comprises a multicomponent reaction of an amine, a carboxylic acid derivative, and an azide source. On the basis of the availability of the archetypical starting materials, this method provided very versatile synthetic access to 1,5-disubstituted tetrazoles. The usefulness of this method was demonstrated in the synthesis of biologically important fused tetrazole scaffolds and the marketed drug cilostazol.

METHOD FOR PRODUCING BIARYL COMPOUND

Provided is a novel production method capable of producing a biaryl compound, which is useful as an intermediate for angiotensin II receptor blockers, economically under conditions suitable for industrial production. A production method of a biaryl compound of the formula [3] or a salt thereof, including reacting a 2-phenylazole derivative of the formula [1] or a salt thereof, with a benzene derivative of the formula [2] or a salt thereof in the presence of a metal catalyst, a base, and one or more kinds of compounds selected from the group consisting of (a) a monocarboxylic acid metal salt, (b) a dicarboxylic acid metal salt, (c) a sulfonic acid metal salt, and (d) a phosphate or phosphoric amide metal salt represented by RAxP(O)(OM)y wherein each symbol is as defined in the DESCRIPTION.

O -iodoxybenzoic acid mediated oxidative desulfurization initiated domino reactions for synthesis of azoles

A systematic exploration of thiophilic ability of o-iodoxybenzoic acid (IBX) for oxidative desulfurization to trigger domino reactions leading to new methodologies for synthesis of different azoles is described. A variety of highly substituted oxadiazoles, thiadiazoles, triazoles, and tetrazoles have been successfully synthesized in good to excellent yields, starting from readily accessible thiosemicarbazides, bis-diarylthiourea, 1,3-disubtituted thiourea, and thioamides.

PROCESS FOR PRODUCTION OF BIPHENYL DERIVATIVE

The invention provides a production method of a biaryltetrazole derivative useful as an intermediate for an angiotensin II receptor antagonist. The method comprises reacting an aryltetrazole derivative with a benzene derivative, deprotecting or reducing the resulting compound, and halogenating the deprotected or reduced compound

Highly efficient synthesis of 5-substituted 1H-tetrazoles catalyzed by Cu-Zn alloy nanopowder, conversion into 1,5- and 2,5-disubstituted tetrazoles, and synthesis and NMR studies of new tetrazolium ionic liquids

A series of 5-substituted 1H-tetrazoles were synthesized through [3+2] cycloaddition reactions between nitriles RCN and NaN3 in the presence of Cu-Zn alloy nanopowder as catalyst. The 1,5-dibutyl, 1-butyl-5-hexyl, 2,5-dibutyl, and 2-butyl-5-hexyl derivatives were then used as building blocks to synthesize several novel tetrazolium ionic liquids (ILs) with EtSO 4-, OTf-, and NTf2- counterions. Whereas alkylation of the 2,5-dialkyltetrazoles selectively gave the N-4 alkylated onium salts, with the 1,5-dialkyl derivatives approximately 1:1 mixtures of two tetrazolium salts were formed by alkylation at N-3 and N-4. The triflate and ethyl sulfate salts are room-temperature ILs that are hydrophilic, whereas the NTf2 salts are low-melting ILs and are hydrophobic. The resulting tetrazolium-based ionic liquids were studied by various multinuclear and 2D NMR techniques including natural abundance 15N and 1H/15N correlations.