Benzyl [(diethoxyphosphoryl)difluoromethyl]-2-(trifluoromethylsulfonyloxy)benzoate

Base Information

Chemical Name:Benzyl [(diethoxyphosphoryl)difluoromethyl]-2-(trifluoromethylsulfonyloxy)benzoate
CAS No.:306753-77-5
Molecular Formula:C₂₀H₂₀F₅O₈PS
Molecular Weight:546.406
Hs Code.:

Synonyms:Benzyl [(diethoxyphosphoryl)difluoromethyl]-2-(trifluoromethylsulfonyloxy)benzoate

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Chemical Property of Benzyl [(diethoxyphosphoryl)difluoromethyl]-2-(trifluoromethylsulfonyloxy)benzoate

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Technology Process of Benzyl [(diethoxyphosphoryl)difluoromethyl]-2-(trifluoromethylsulfonyloxy)benzoate

There total 4 articles about Benzyl [(diethoxyphosphoryl)difluoromethyl]-2-(trifluoromethylsulfonyloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 65094-22-6
diethyl (bromodifluoromethyl)phosphonate

: 306753-76-4
Benzyl (5-iodo-2-trifluoromethylsulfonyloxy)benzoate

: 306753-77-5
Benzyl [(diethoxyphosphoryl)difluoromethyl]-2-(trifluoromethylsulfonyloxy)benzoate

Guidance literature:: diethyl (bromodifluoromethyl)phosphonate; With zinc; In N,N-dimethyl acetamide; at 20 ℃; for 3h;

With copper(I) bromide; In N,N-dimethyl acetamide; at 20 ℃; for 0.5h;

Benzyl (5-iodo-2-trifluoromethylsulfonyloxy)benzoate; In N,N-dimethyl acetamide; at 20 ℃; for 27h; Further stages.;
DOI:10.1039/b004187o

Reference yield:

: 119-30-2
2-hydroxy-5-iodobenzoic acid

: 306753-77-5
Benzyl [(diethoxyphosphoryl)difluoromethyl]-2-(trifluoromethylsulfonyloxy)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 82 percent / KF / dimethylformamide / 2 h / 100 °C

2.1: 79 percent / pyridine / 18 h / 0 °C

3.1: Zn / N,N-dimethyl-acetamide / 3 h / 20 °C

3.2: CuBr / N,N-dimethyl-acetamide / 0.5 h / 20 °C

3.3: 67 percent / N,N-dimethyl-acetamide / 27 h / 20 °C

With pyridine; potassium fluoride; zinc; In N,N-dimethyl acetamide; N,N-dimethyl-formamide; 1.1: Substitution / 2.1: Substitution / 3.1: Metallation / 3.2: Substitution / 3.3: Substitution;
DOI:10.1039/b004187o

Reference yield:

: 100-39-0
benzyl bromide

: 306753-77-5
Benzyl [(diethoxyphosphoryl)difluoromethyl]-2-(trifluoromethylsulfonyloxy)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 82 percent / KF / dimethylformamide / 2 h / 100 °C

2.1: 79 percent / pyridine / 18 h / 0 °C

3.1: Zn / N,N-dimethyl-acetamide / 3 h / 20 °C

3.2: CuBr / N,N-dimethyl-acetamide / 0.5 h / 20 °C

3.3: 67 percent / N,N-dimethyl-acetamide / 27 h / 20 °C

With pyridine; potassium fluoride; zinc; In N,N-dimethyl acetamide; N,N-dimethyl-formamide; 1.1: Substitution / 2.1: Substitution / 3.1: Metallation / 3.2: Substitution / 3.3: Substitution;
DOI:10.1039/b004187o