3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid N'-phenyl-hydrazide

Base Information

Chemical Name:3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid N'-phenyl-hydrazide
CAS No.:113942-37-3
Molecular Formula:C₁₃H₁₂ClN₇O₂
Molecular Weight:333.737
Hs Code.:

Synonyms:3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid N'-phenyl-hydrazide

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Chemical Property of 3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid N'-phenyl-hydrazide

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Technology Process of 3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid N'-phenyl-hydrazide

There total 4 articles about 3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid N'-phenyl-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 113942-57-7
3-(2-chloroethyl)-4-oxoimidazo<5,1-d>-1,2,3,5-tetrazine-8-carbonyl chloride

: 100-63-0
phenylhydrazine

: 113942-37-3
3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid N'-phenyl-hydrazide

Guidance literature:: In tetrahydrofuran; water; for 0.5h;
DOI:10.1021/jm00167a018

Reference yield:

: 113942-31-7
benzyl 3-(2-chloroethyl)-3H-4-oxoimidazo<5,1-d>-1,2,3,5-tetrazine-8-carboxylate

: 113942-37-3
3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid N'-phenyl-hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / H₂ / palladium on charcoal (10percent)

2: 99 percent / thionyl chloride, N,N-dimethylformamide / 2.5 h / Heating

3: 71 percent / tetrahydrofuran; H₂O / 0.5 h

With thionyl chloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; water;
DOI:10.1021/jm00167a018

Reference yield:

: 85622-95-3
mitozolomide

: 113942-37-3
3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid N'-phenyl-hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / concd. sulfuric acid, sodium nitrite / H₂O / 2.5 h / 35 °C

2: 99 percent / thionyl chloride, N,N-dimethylformamide / 2.5 h / Heating

3: 71 percent / tetrahydrofuran; H₂O / 0.5 h

With thionyl chloride; sulfuric acid; N,N-dimethyl-formamide; sodium nitrite; In tetrahydrofuran; water;
DOI:10.1021/jm00167a018