rac-tert-butyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-(4-fluorophenyl)ethyl]carbamate

Base Information

• Chemical Name: rac-tert-butyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-(4-fluorophenyl)ethyl]carbamate
• CAS No.: 1609344-56-0
• Molecular Formula: C₂₁H₂₁FN₂O₄
• Molecular Weight: 384.407
• Mol file: 1609344-56-0.mol

Synonyms:rac-tert-butyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-(4-fluorophenyl)ethyl]carbamate

Chemical Property of rac-tert-butyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-(4-fluorophenyl)ethyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-tert-butyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-(4-fluorophenyl)ethyl]carbamate

There total 2 articles about rac-tert-butyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-(4-fluorophenyl)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

rac-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenyl)propanoic acid (354148-17-7) + tert-butyl alcohol (75-65-0) → rac-tert-butyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-(4-fluorophenyl)ethyl]carbamate (1609344-56-0)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; diphenyl phosphoryl azide; triethylamine; In toluene; Inert atmosphere; Reflux;

Reference yield:

phthalic anhydride (85-44-9) + 3-amino-3-(4-fluorophenyl)propanoic acid (325-89-3) → rac-tert-butyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-(4-fluorophenyl)ethyl]carbamate (1609344-56-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 135 °C

2: triethylamine; 1,4-diaza-bicyclo[2.2.2]octane; diphenyl phosphoryl azide / toluene / Inert atmosphere; Reflux

With 1,4-diaza-bicyclo[2.2.2]octane; diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; toluene;

upstream raw materials:

phthalic anhydride

3-amino-3-(4-fluorophenyl)propanoic acid

rac-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenyl)propanoic acid

tert-butyl alcohol