rac-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenyl)propanoic acid

Base Information

Chemical Name:rac-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenyl)propanoic acid
CAS No.:354148-17-7
Molecular Formula:C₁₇H₁₂FNO₄
Molecular Weight:313.285
Hs Code.:

Synonyms:rac-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenyl)propanoic acid

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Chemical Property of rac-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenyl)propanoic acid

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Technology Process of rac-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenyl)propanoic acid

There total 3 articles about rac-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 85-44-9
phthalic anhydride

: 325-89-3
3-amino-3-(4-fluorophenyl)propanoic acid

: 354148-17-7
rac-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenyl)propanoic acid

Guidance literature:: at 250 ℃;
DOI:10.1016/j.ejmech.2018.07.005

Reference yield:

: 136918-14-4,85-41-6
phthalimide

: 405-99-2
para-fluorostyrene

: 201230-82-2
carbon monoxide

: 354148-17-7
rac-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenyl)propanoic acid

Guidance literature:: With palladium(II) trifluoroacetate; [bis(acetoxy)iodo]benzene; In toluene; acetonitrile; at 60 ℃; for 26h; under 760.051 Torr; Schlenk technique;
DOI:10.1021/jacs.5b00719

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 354148-17-7
rac-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / butan-1-ol / Reflux

2: 250 °C

With ammonium acetate; In butan-1-ol;
DOI:10.1016/j.ejmech.2018.07.005