3,7-bis(2-hydroxyethyl)-1,5-bis<4-(benzyloxy)phenyl>-3,7-diazabicyclo<3.3.1>nonan-9-one

Base Information

• Chemical Name: 3,7-bis(2-hydroxyethyl)-1,5-bis<4-(benzyloxy)phenyl>-3,7-diazabicyclo<3.3.1>nonan-9-one
• CAS No.: 157108-64-0
• Molecular Formula: C₃₇H₄₀N₂O₅
• Molecular Weight: 592.735
• Mol file: 157108-64-0.mol

Synonyms:3,7-bis(2-hydroxyethyl)-1,5-bis<4-(benzyloxy)phenyl>-3,7-diazabicyclo<3.3.1>nonan-9-one

Chemical Property of 3,7-bis(2-hydroxyethyl)-1,5-bis<4-(benzyloxy)phenyl>-3,7-diazabicyclo<3.3.1>nonan-9-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,7-bis(2-hydroxyethyl)-1,5-bis<4-(benzyloxy)phenyl>-3,7-diazabicyclo<3.3.1>nonan-9-one

There total 4 articles about 3,7-bis(2-hydroxyethyl)-1,5-bis<4-(benzyloxy)phenyl>-3,7-diazabicyclo<3.3.1>nonan-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1,3-bis<4-(benzyloxy)phenyl>propan-2-one (138434-75-0) + ethanolamine (141-43-5) → 3,7-bis(2-hydroxyethyl)-1,5-bis<4-(benzyloxy)phenyl>-3,7-diazabicyclo<3.3.1>nonan-9-one (157108-64-0)

Guidance literature:

With acetic acid; In ethanol; for 5h; Heating;

DOI:10.1002/hlca.19940770320

Reference yield:

4-Methoxyphenylacetic acid (104-01-8) → 3,7-bis(2-hydroxyethyl)-1,5-bis<4-(benzyloxy)phenyl>-3,7-diazabicyclo<3.3.1>nonan-9-one (157108-64-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) MnCl₂*4H₂O, Na₂CO₃ / 1.) H₂O, 2.) 200-250 deg C, 0.5 Torr

2: 95 percent / 48percent aq. HBr / acetic acid / 4 h / Heating

3: 87 percent / K₂CO₃ / acetone / 12 h / Heating

4: 37 percent / AcOH / ethanol / 5 h / Heating

With hydrogen bromide; sodium carbonate; potassium carbonate; acetic acid; manganese(ll) chloride; In ethanol; acetic acid; acetone;

DOI:10.1002/hlca.19940770320

Reference yield:

1,3-bis-(4-hydroxy-phenyl)-acetone (71356-08-6) → 3,7-bis(2-hydroxyethyl)-1,5-bis<4-(benzyloxy)phenyl>-3,7-diazabicyclo<3.3.1>nonan-9-one (157108-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / K₂CO₃ / acetone / 12 h / Heating

2: 37 percent / AcOH / ethanol / 5 h / Heating

With potassium carbonate; acetic acid; In ethanol; acetone;

DOI:10.1002/hlca.19940770320

upstream raw materials:

formaldehyd

1,3-bis<4-(benzyloxy)phenyl>propan-2-one

ethanolamine

4-Methoxyphenylacetic acid