methyl 2-[(6S,9S,14aS,15S,16S,20S,23S,25aS,2R,11R)-2,11,15-trihydroxy-6-((1R)-1-hydroxyethyl)-23-((1S)-1-hydroxy-2-(4-hydroxyphenyl)-2-methoxycarbonylmethylsulfanylethyl)-20-hydroxymethyl-16-methyl-9-(11-methyltridecylcarboxamido)-5,8,14,19,22,25-hexaoxoperhydrodiazolo[2,1-c:1-l][1,4,7,10,13,16]hexaazacyclohenicosin-12-ylsulfanyl]acetate

Base Information

Chemical Name:methyl 2-[(6S,9S,14aS,15S,16S,20S,23S,25aS,2R,11R)-2,11,15-trihydroxy-6-((1R)-1-hydroxyethyl)-23-((1S)-1-hydroxy-2-(4-hydroxyphenyl)-2-methoxycarbonylmethylsulfanylethyl)-20-hydroxymethyl-16-methyl-9-(11-methyltridecylcarboxamido)-5,8,14,19,22,25-hexaoxoperhydrodiazolo[2,1-c:1-l][1,4,7,10,13,16]hexaazacyclohenicosin-12-ylsulfanyl]acetate
CAS No.:321745-64-6
Molecular Formula:C₅₄H₈₅N₇O₁₈S₂
Molecular Weight:1184.44
Hs Code.:

methyl 2-[(6S,9S,14aS,15S,16S,20S,23S,25aS,2R,11R)-2,11,15-trihydroxy-6-((1R)-1-hydroxyethyl)-23-((1S)-1-hydroxy-2-(4-hydroxyphenyl)-2-methoxycarbonylmethylsulfanylethyl)-20-hydroxymethyl-16-methyl-9-(11-methyltridecylcarboxamido)-5,8,14,19,22,25-hexaoxoperhydrodiazolo[2,1-c:1-l][1,4,7,10,13,16]hexaazacyclohenicosin-12-ylsulfanyl]acetate

Synonyms:methyl 2-[(6S,9S,14aS,15S,16S,20S,23S,25aS,2R,11R)-2,11,15-trihydroxy-6-((1R)-1-hydroxyethyl)-23-((1S)-1-hydroxy-2-(4-hydroxyphenyl)-2-methoxycarbonylmethylsulfanylethyl)-20-hydroxymethyl-16-methyl-9-(11-methyltridecylcarboxamido)-5,8,14,19,22,25-hexaoxoperhydrodiazolo[2,1-c:1-l][1,4,7,10,13,16]hexaazacyclohenicosin-12-ylsulfanyl]acetate

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Chemical Property of methyl 2-[(6S,9S,14aS,15S,16S,20S,23S,25aS,2R,11R)-2,11,15-trihydroxy-6-((1R)-1-hydroxyethyl)-23-((1S)-1-hydroxy-2-(4-hydroxyphenyl)-2-methoxycarbonylmethylsulfanylethyl)-20-hydroxymethyl-16-methyl-9-(11-methyltridecylcarboxamido)-5,8,14,19,22,25-hexaoxoperhydrodiazolo[2,1-c:1-l][1,4,7,10,13,16]hexaazacyclohenicosin-12-ylsulfanyl]acetate

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Technology Process of methyl 2-[(6S,9S,14aS,15S,16S,20S,23S,25aS,2R,11R)-2,11,15-trihydroxy-6-((1R)-1-hydroxyethyl)-23-((1S)-1-hydroxy-2-(4-hydroxyphenyl)-2-methoxycarbonylmethylsulfanylethyl)-20-hydroxymethyl-16-methyl-9-(11-methyltridecylcarboxamido)-5,8,14,19,22,25-hexaoxoperhydrodiazolo[2,1-c:1-l][1,4,7,10,13,16]hexaazacyclohenicosin-12-ylsulfanyl]acetate

There total 1 articles about methyl 2-[(6S,9S,14aS,15S,16S,20S,23S,25aS,2R,11R)-2,11,15-trihydroxy-6-((1R)-1-hydroxyethyl)-23-((1S)-1-hydroxy-2-(4-hydroxyphenyl)-2-methoxycarbonylmethylsulfanylethyl)-20-hydroxymethyl-16-methyl-9-(11-methyltridecylcarboxamido)-5,8,14,19,22,25-hexaoxoperhydrodiazolo[2,1-c:1-l][1,4,7,10,13,16]hexaazacyclohenicosin-12-ylsulfanyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.75%

: 2365-48-2
Methyl thioglycolate

: 108351-20-8
mulundocandin

: 321661-48-7
methyl 2-[(6S,9S,14aS,15S,16S,20S,23S,25aS,2R,11R)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((1R)-1-hydroxyethyl)-20-hydroxymethyl-16-methyl-9-(11-methyltridecylcarboxamido)-5,8,14,19,22,25-hexaoxoperhydrodiazolo[2,1-c:1-l][1,4,7,10,13,16]hexaazacyclohenicosin-12-ylsulfanyl]acetate

: 321745-64-6
methyl 2-[(6S,9S,14aS,15S,16S,20S,23S,25aS,2R,11R)-2,11,15-trihydroxy-6-((1R)-1-hydroxyethyl)-23-((1S)-1-hydroxy-2-(4-hydroxyphenyl)-2-methoxycarbonylmethylsulfanylethyl)-20-hydroxymethyl-16-methyl-9-(11-methyltridecylcarboxamido)-5,8,14,19,22,25-hexaoxoperhydrodiazolo[2,1-c:1-l][1,4,7,10,13,16]hexaazacyclohenicosin-12-ylsulfanyl]acetate

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; at 20 ℃; for 1.5h;
DOI:10.1016/j.bmc.2003.08.003

Reference yield: 84.9%

: 321745-64-6
methyl 2-[(6S,9S,14aS,15S,16S,20S,23S,25aS,2R,11R)-2,11,15-trihydroxy-6-((1R)-1-hydroxyethyl)-23-((1S)-1-hydroxy-2-(4-hydroxyphenyl)-2-methoxycarbonylmethylsulfanylethyl)-20-hydroxymethyl-16-methyl-9-(11-methyltridecylcarboxamido)-5,8,14,19,22,25-hexaoxoperhydrodiazolo[2,1-c:1-l][1,4,7,10,13,16]hexaazacyclohenicosin-12-ylsulfanyl]acetate

: C₅₄H₈₅N₇O₂₂S₂

Guidance literature:: With oxone; In water; acetonitrile; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2003.08.003

Reference yield:

: 321745-64-6
methyl 2-[(6S,9S,14aS,15S,16S,20S,23S,25aS,2R,11R)-2,11,15-trihydroxy-6-((1R)-1-hydroxyethyl)-23-((1S)-1-hydroxy-2-(4-hydroxyphenyl)-2-methoxycarbonylmethylsulfanylethyl)-20-hydroxymethyl-16-methyl-9-(11-methyltridecylcarboxamido)-5,8,14,19,22,25-hexaoxoperhydrodiazolo[2,1-c:1-l][1,4,7,10,13,16]hexaazacyclohenicosin-12-ylsulfanyl]acetate

: N₁-[(6S,9S,14aS,15S,16S,20S,23S,25aS,2R,11R)-12-azido-23-((1R)-2-azido-1-hydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((1S)-1-hydroxyethyl)-20-hydroxymethyl-16-methyl-5,8,14,19,22,25-hexaoxoperhydrodiazolo[2,1-c:2,1-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl]-12-methyltetradecanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 84.9 percent / OXONE(R) / acetonitrile; H₂O / 1 h / 20 °C

2: 67.8 percent / NaN₃ / dioxane / 2 h / 45 - 50 °C

With sodium azide; oxone; In 1,4-dioxane; water; acetonitrile;
DOI:10.1016/j.bmc.2003.08.003