2-methoxy-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)aniline

Base Information

Chemical Name:2-methoxy-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)aniline
CAS No.:1609394-07-1
Molecular Formula:C₁₅H₂₄N₄O₂Si
Molecular Weight:320.467
Hs Code.:

Synonyms:2-methoxy-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)aniline

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Chemical Property of 2-methoxy-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)aniline

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Technology Process of 2-methoxy-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)aniline

There total 9 articles about 2-methoxy-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1609394-06-0
3-(2-methoxy-3-nitrophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazole

: 1609394-07-1
2-methoxy-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)aniline

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; for 4h; Inert atmosphere;

Reference yield: 85.0%

: 1260599-41-4
3-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazole

: 1609393-90-9
2-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

: 1609394-07-1
2-methoxy-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)aniline

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; Inert atmosphere;

Reference yield:

: 22621-41-6
2-hydroxy-3-nitro-benzoic acid methyl ester

: 1609394-07-1
2-methoxy-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)aniline

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 - 60 °C

2.1: ammonium hydroxide; ammonia / water; methanol / 20 - 25 °C / Sealed tube

3.1: 0.5 h / 95 °C

3.2: 4 h / 20 - 25 °C / Cooling with ice

4.1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 3 h / 20 - 25 °C

5.1: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / Inert atmosphere

With dmap; ammonium hydroxide; palladium 10% on activated carbon; ammonia; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;