METHYL-2-METHOXY-3-NITROBENZOATE

Base Information

• Chemical Name: METHYL-2-METHOXY-3-NITROBENZOATE
• CAS No.: 90564-26-4
• Molecular Formula: C9H9 N O5
• Molecular Weight: 211.174
• Hs Code.: 2918990090
• Mol file: 90564-26-4.mol

Synonyms:o-Anisicacid, 3-nitro-, methyl ester (6CI,7CI); Methyl 2-methoxy-3-nitrobenzoate

Chemical Property of METHYL-2-METHOXY-3-NITROBENZOATE

Chemical Property:

• Melting Point: 60 °C
• Boiling Point: 341.9±22.0 °C(Predicted)
• PSA: 81.35000
• Density: 1.294±0.06 g/cm3(Predicted)
• LogP: 1.91320
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

Methyl 2-methoxy-3-nitrobenzoate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL-2-METHOXY-3-NITROBENZOATE

There total 9 articles about METHYL-2-METHOXY-3-NITROBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-nitrosalicylic acid (85-38-1) + methyl iodide (74-88-4) → 2-methoxy-3-nitro-benzoic acid methyl ester (90564-26-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1016/j.tetlet.2008.06.050

Reference yield: 98.8%

2-hydroxy-3-nitro-benzoic acid methyl ester (22621-41-6) + methyl iodide (74-88-4) → 2-methoxy-3-nitro-benzoic acid methyl ester (90564-26-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 1h;

Reference yield: 98.0%

2-fluoro-3-nitrobenzoic acid methyl ester (946126-94-9) + sodium methylate (124-41-4) → 2-methoxy-3-nitro-benzoic acid methyl ester (90564-26-4)

Guidance literature:

In methanol; at 20 ℃; for 4h;

upstream raw materials:

diazomethane

3-nitrosalicylic acid

methanol

2-methoxy-3-nitrobenzoic acid

Downstream raw materials:

(2-methoxy-3-nitro-phenyl)-methanol

2-hydroxy-3-nitro-benzoic acid methyl ester

2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl) aniline

3-(2-methoxy-3-nitrophenyl)-1-methyl-1H-1,2,4-triazole

Refernces

• 1、 -. "-". . . Retrieved 2022/01/12.
• 2、 -. "Compound used as CDK7 kinase inhibitor and application thereof". Paragraph 0216; 0220-0221. . Retrieved 2021/04/17.