(4R,5R)-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone

Base Information

• Chemical Name: (4R,5R)-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone
• CAS No.: 130115-12-7
• Molecular Formula: C₂₁H₂₃NO₅
• Molecular Weight: 369.417

Synonyms:(4R,5R)-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone

Chemical Property of (4R,5R)-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone

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Technology Process of (4R,5R)-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone

There total 17 articles about (4R,5R)-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2S,3R,4R)-3-Amino-2-benzyloxy-4-hydroxy-4-phenyl-butyric acid isopropyl ester (130115-10-5,139630-60-7) + trichloromethyl chloroformate (503-38-8) → (S)-Benzyloxy-((4R,5S)-2-oxo-5-phenyl-oxazolidin-4-yl)-acetic acid isopropyl ester (130115-12-7,139580-08-8,141280-89-9)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 0.166667h;

DOI:10.1016/S0040-4020(01)88510-0

Reference yield: 93.0%

(2S,3R,4S)-3-Amino-2-benzyloxy-4-hydroxy-4-phenyl-butyric acid isopropyl ester (130115-10-5,139630-60-7) + trichloromethyl chloroformate (503-38-8) → (S)-Benzyloxy-((4R,5S)-2-oxo-5-phenyl-oxazolidin-4-yl)-acetic acid isopropyl ester (130115-12-7,139580-08-8,141280-89-9)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 0.166667h;

DOI:10.1016/S0040-4039(00)89018-8

Reference yield: 90.0%

isopropyl (2R,3S,4R)-3-amino-2-benzyloxy-4-hydroxybutyrate (130115-10-5,139630-60-7) + trichloromethyl chloroformate (503-38-8) → (4R,5R)-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone (130115-12-7)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 0.166667h;

DOI:10.1016/S0040-4020(01)88510-0

upstream raw materials:

(2R,3S,4R)-3-Amino-2-benzyloxy-4-hydroxy-4-phenyl-butyric acid isopropyl ester

trichloromethyl chloroformate

isopropyl (2R,3S,4R)-3-amino-2-benzyloxy-4-hydroxybutyrate

Benzyloxyacetyl chloride

Downstream raw materials:

isopropyl (2R,3S)-3-amino-2-hydroxy-4-phenylbutyrate

2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester

(2R,3S)-nor-C-statine hydrochloride

isopropyl (2R,3S)-3-acetamido-2-acetoxy-4-cyclohexylbutyrate

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