3-((5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazol-2ylthio)methyl)benzonitrile

Base Information

Chemical Name:3-((5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazol-2ylthio)methyl)benzonitrile
CAS No.:1374671-53-0
Molecular Formula:C₁₈H₁₃N₃O₃S
Molecular Weight:351.386
Hs Code.:

Synonyms:3-((5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazol-2ylthio)methyl)benzonitrile

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Chemical Property of 3-((5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazol-2ylthio)methyl)benzonitrile

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Technology Process of 3-((5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazol-2ylthio)methyl)benzonitrile

There total 2 articles about 3-((5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazol-2ylthio)methyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 928710-56-9
5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazole-2-thiol

: 28188-41-2
m-(bromomethyl)benzonitrile

: 1374671-53-0
3-((5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazol-2ylthio)methyl)benzonitrile

Guidance literature:: With sodium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jm300309a

Reference yield:

: 4442-54-0
2,3-dihydro-1,4-benzodioxin-6-carboxylic acid

: 1374671-53-0
3-((5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazol-2ylthio)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 13 h / 0 - 50 °C

2: hydrazine hydrate / ethanol / 48 h / Reflux

3: triethylamine / ethanol / Reflux; Inert atmosphere

4: sodium hydroxide / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

With hydrazine hydrate; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm300309a