(S)-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

Base Information

Chemical Name:(S)-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile
CAS No.:1597528-77-2
Molecular Formula:C₁₅H₁₅N₅O
Molecular Weight:281.317
Hs Code.:

Synonyms:(S)-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

Suppliers and Price of (S)-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

There total 3 articles about (S)-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 956317-36-5
2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

: (2S)-pyrrolidine-2-carbonitrile hydrochloride

: 1597528-77-2
(S)-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

Guidance literature:: 2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

(2S)-pyrrolidine-2-carbonitrile hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1002/cmdc.201900618

Reference yield:

: 956317-36-5
2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

: 204387-53-1
(2S)-pyrrolidine-2-carbonitrile

: 1597528-77-2
(S)-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 52548-14-8
2-iodoyl-5-methylbenzoic acid

: 1597528-77-2
(S)-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With copper(l) iodide; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201900618