(S)-N-hydroxy-1-(5-methyl-2-[1,2,3]triazol-2-yl-benzoyl)pyrrolidine-2-carboxamidine

Base Information

Chemical Name:(S)-N-hydroxy-1-(5-methyl-2-[1,2,3]triazol-2-yl-benzoyl)pyrrolidine-2-carboxamidine
CAS No.:1597528-83-0
Molecular Formula:C₁₅H₁₈N₆O₂
Molecular Weight:314.347
Hs Code.:

Synonyms:(S)-N-hydroxy-1-(5-methyl-2-[1,2,3]triazol-2-yl-benzoyl)pyrrolidine-2-carboxamidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-hydroxy-1-(5-methyl-2-[1,2,3]triazol-2-yl-benzoyl)pyrrolidine-2-carboxamidine

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Technology Process of (S)-N-hydroxy-1-(5-methyl-2-[1,2,3]triazol-2-yl-benzoyl)pyrrolidine-2-carboxamidine

There total 4 articles about (S)-N-hydroxy-1-(5-methyl-2-[1,2,3]triazol-2-yl-benzoyl)pyrrolidine-2-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1597528-77-2
(S)-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

: 1597528-83-0
(S)-N-hydroxy-1-(5-methyl-2-[1,2,3]triazol-2-yl-benzoyl)pyrrolidine-2-carboxamidine

Guidance literature:: With hydroxylamine hydrochloride; potassium tert-butylate; In methanol; at 75 ℃; Inert atmosphere;
DOI:10.1002/cmdc.201900618

Reference yield:

: 956317-36-5
2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

: 1597528-83-0
(S)-N-hydroxy-1-(5-methyl-2-[1,2,3]triazol-2-yl-benzoyl)pyrrolidine-2-carboxamidine

Guidance literature:: Multi-step reaction with 2 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

2: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / 1 h / 20 °C

With hydroxylamine hydrochloride; sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

Reference yield:

: 52548-14-8
2-iodoyl-5-methylbenzoic acid

: 1597528-83-0
(S)-N-hydroxy-1-(5-methyl-2-[1,2,3]triazol-2-yl-benzoyl)pyrrolidine-2-carboxamidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; potassium tert-butylate / methanol / 75 °C / Inert atmosphere

With copper(l) iodide; hydroxylamine hydrochloride; potassium tert-butylate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201900618